The construction of the school began on March 16, 1985. During this time,
kindergarten to fourth grade classes were temporarily held first at
La Salle Green Hills. Construction was delayed because of the costs and logistics that were involved in building a school on a mountain. Classes were finally transferred to the Antipolo campus on January 13, 1986, and were housed in two buildings. A third building was completed in the summer of 1987, with a fourth one completed in 1989. The school's St. Benilde Multi-purpose Hall was finished in 1991, while the
high school and laboratory-library buildings were completed in 1994. The Tertiary Education Unit was launched in 1998, with BS in elementary education and BS in accountancy offered initially. In 2006, La Salle College became part of
De La Salle Philippines, Inc. In 2014,
De La Salle–College of Saint Benilde acquired a building in the city proper for the Tertiary Education Unit of La Salle College Antipolo. La Salle College was 30 years old in 2016. The senior high school also opened during this year. In 2018, the Tertiary Education unit of La Salle College Antipolo merged with
De La Salle-College of Saint Benilde following Benilde's construction of a multistorey building in the city proper of Antipolo. The campus is called DLS-CSB - Antipolo. With the college department spun off, La Salle College Antipolo focused on providing basic education from kindergarten to senior high school. In 2019, LSCA opened the preschool campus at the town proper of Antipolo offering Nursery 1, Nursery 2, and Kindergarten. The campus is situated on Sen. L. Sumulong Street in San Jose, Antipolo. ==Academics==