X-Treme X-Men Lady Mastermind is one of three daughters of
Jason Wyngarde, the original Mastermind. She has an intense hatred for her half-sister, Martinique (though she was the first to use their now-shared codename). She is hated by her sister for "stealing the spotlight", while she hates her sister for being a "
skank", with the two of them constantly insulting each other. In an attempt to make Sage work for Shaw again, Lady Mastermind placed her in a series of
illusions. However, with the assistance of
Lifeguard, the daughter of Viceroy, Sage was able to break the illusion and reflect Regan's powers back against her, leaving her in a
vegetative state.
Joining The X-Men Regan is one of few mutants who retain their powers after
M-Day.
Cannonball and
Iceman find a comatose Regan, along with a partially disassembled
Karima Shapandar. It is stated that Regan fell victim to scientists of the Fordyce Clinic who were trying to determine if a person can catch mutation like a disease. Regan finally awakens from her coma after her powers are temporarily hijacked by
Serafina. She joins
Rogue's strike force/field team, but Rogue tells Regan that she is only wearing the X-Men uniform because she was found with nothing more than a white sheet. Soon afterwards, the team is ambushed by Pandemic's forces, which capture Rogue and teleport to an unknown location. Eventually, Shapandar restarts the teleportation device, but Regan is teleported up high into the air and fell from an enormous height. Luckily,
Iceman catches her before she hit the ground.
Mystique, who was also teleported by the machine, was not as lucky as she was, and vanished. Regan and Iceman soon regroup with Shapandar, and the trio begin to search for Pandemic. They find Pandemic and defeat him, but Rogue is infected with Strain 88 in the process. The team goes to
Cable's island utopia of Providence to find a cure for Rogue. While there the island is attacked by an ancient
Shi'ar superweapon known as the Hecatomb, forcing Regan and the rest of the team to fight the psionic horror. The weapon is eventually defeated thanks to Rogue's power-absorption abilities, now supercharged due to Strain 88.
Marauders When Rogue's team of X-Men goes to one of Mystique's safe-houses an intruder alarm later goes off. Initially confused by the seemingly invisible nature of their opponents, the X-Men are caught off guard when Regan drops her illusionary cloak to reveal the
Marauders. Regan later fights alongside the other Marauders in Flint, Michigan, against Iceman and Cannonball, as both sides try to obtain the Diaries of
Destiny.
Messiah Complex Along with fellow Marauders
Sunfire,
Gambit,
Prism,
Blockbuster,
Malice, and
Scalphunter, Regan travels to Cooperstown, Alaska to find the baby but instead come across the
Purifiers and they come to blows. The next time Regan is seen is when the X-Men send a strike force to confront the Marauders. Working with Malice, she disguises an unconscious
Scrambler as
Angel and Malice drops him on
Wolverine cancelling out his healing factor. Malice says this illusion is courtesy of Regan and boasts how she is a retired X-Man.
Nightcrawler teleports in and kicks her in the head knocking her out. When the X-Men,
X-Factor, and
X-Force arrive on
Muir Island, Lady Mastermind attempts to cast an illusion to hide the Marauders. However, Wolverine picks up her scent and stabs her in the abdomen.
Sisterhood of Mutants The Sisterhood approaches Regan, who is at a graveyard mourning
her father. At first, Regan points her gun to
Madelyne Pryor's head. When Madelyne promises to resurrect Regan's father, Regan joins - this, however, disgusts Martinique. Later in San Francisco, the Sisterhood perform a spell involving
Kwannon's body and a captive
Psylocke, restoring her to her original body. While trapped, Emma unexpectedly finds what seems to be
Jean Grey communicating to her, and seemingly aiding Emma. Emma becomes the first person not to fall for Regan's illusion, prompting Regan to worry. Emma then savagely beats Regan, calling her a traitor to her kind. Emma leaves Regan's bruised and battered body upon the ground, though the Sisterhood later pick her up and escape. When they return to base, the Red Queen orders Regan, Martinique, and Psylocke to stay while she and the other members of the Sisterhood go to Jean Grey's grave. They take on
Storm,
Dazzler,
Karma, and Emma Frost, who savagely beats her again. After the Red Queen's defeat,
Spiral collects the Sisterhood and teleports off.
Pixie Strikes Back In the second issue of
X-Men: Pixie Strikes Back, the mother of X-Man
Pixie, Mrs. Gwynn, teleports herself to the Wyngarde Mansion, where Regan is fighting with Martinique and reveals Pixie is their half-sister. Teaming up with Mrs. Gwynn who offers the sisters power in exchange for their help, they attempt to track down Pixie after being kidnapped by
Saturnine. During the final confrontation with the demon, Pixie teleports both Regan and Martinique away when X-23 attempts to attack them.
All-New X-Men Sometime later, Regan ends up incarcerated in the
Raft. Together with
Sabretooth, Mystique breaks Regan out of jail and offers her a chance to get rich as well as informing Regan of Charles Xavier's death. Regan agrees to join them and after being held up by S.H.I.E.L.D. soldiers, Regan casts an illusion to make it seem the soldiers are being attacked by zombie Avengers so the trio can make their escape. Regan is shock to see a live, although time displaced,
Jean Grey back in the present. She uses this opportunity to create an illusion of her
father from his time with the Inner Circle, when he tried to seduce the Dark Phoenix, causing what seemed to be the rebirth, or arrival, of the Phoenix Force once more. However, it was later revealed to be a telepathic illusion created by the time displaced Jean Grey, much to Regan's disappointment. She later boasts to the young Jean that she knows her more than Jean knows her and projects an illusion of Scott making out with Emma. Out of anger, Jean tells her that she projects very convincing illusions, but the difference between Jean's illusions and Regan's was that Jean projected reality, delving into Regan's mind and making her see her darkest fears, which was an image of a sad young woman sitting in a wheelchair. Despite Regan's apathetic attitude, at times she clearly wanted to become better at using her powers and strived to push herself to create even more realistic illusions. She just needed practice. To that end, when she saw
Anole, one of the X-Men's students, she realized she had found the perfect guinea-pig. Anole had skipped out on a first date with a guy because he was afraid that his reptilian appearance would scare him off. Regan latched onto this insecurity and trapped Anole in an illusion that preyed on his fears of rejection. She was having a wonderful time watching the boy succumb to his fears and it got better when a couple of X-Men turned up to help. She immediately trapped them in their own fear-based illusions and the trick worked, for a while at least. As he had faced his fears numerous times, Nightcrawler broke out of Regan's illusion and forced Anole to do the same. Regan's over-confidence worked against her once more when she allowed herself to get too close to the X-Men and she was knocked unconscious.
All-New, Different Marvel Following the rebirth of the Marvel Universe, Regan is revealed to be one of the many mutants poisoned by Terrigen Mist. Suffering from the M-Pox and fearing to die alone, she trapped as many people as she could in illusions and planned to take them with her. Regan was, however, found by
Danielle Moonstar, who tried to reason with her to release the people she put under and let the X-Men help her. At first, Regan refuses and tries to trap Moonstar in an illusion; as Moonstar resisted her illusion, Regan begs her to stop fighting, stating if she is going to die she won't die alone. Persistent, Moonstar tells her that she understand her fear and pain more than she knows, but Regan finds it hard to believe, saying to her that she has no idea what it's like to live with fear. To show how much she understood, Moonstar shows Regan her memories and all the pain she went through, cancelling her illusion in the process. As the M-Pox began killing Regan, she begs Moonstar end her suffering by killing her, unwilling to live with the pain; Moonstar convinces her not to give up and maintain her courage, no matter what happens. Moonstar transports Regan to X-Haven, where the healers managed to stabilize her condition. As Moonstar leaves her to get healed, Regan thanks her for making her see the error of ways.
Rejoining the X-Men After her recovery, Lady Mastermind was eventually welcomed to the new mutant island of
Krakoa, created by Xavier,
Magneto, and
Moira MacTaggert. She entered through the teleportation gateway alongside other villainous and fractious mutants, who had been invited to join the nation in order to heal mutantdom and start over as a whole species together. However she apparently left Krakoa for her own reasons and went to the now abandoned X-Mansion in order to use one of its teleport gates to rejoin the X-Men on Krakoa. There, she is attacked and captured by a horde of
Sidri hatchlings after accidentally disturbing their nest. She instinctively uses her powers to exert some control over them, causing Krakoa to alert the X-Men to investigate. After
Cypher, a member of the scouting party, manages to establish a rapport with the Sidri, Regan is liberated and taken back to Krakoa. During the "
Empyre" storyline, Lady Mastermind is among the psychic mutants who are summoned to Genosha. She is among those who witness
Magik's fight with the Cotatinaught. ==Characteristics==