In 1653, Lady Rachel married her first husband, Francis Vaughan, Lord Vaughan, the eldest son of
Richard Vaughan, 2nd Earl of Carbery. Upon their marriage, she went to live with her father-in-law at
Golden Grove in
Carmarthen, Wales. In 1655, she gave birth to a child, whose sex and name was not recorded as it died shortly after its birth. She became a widow in 1667, which was the same year her father died. She, her older sister, Elizabeth, Viscountess Campden, and their
younger half-sister, who was also named Elizabeth (she became Countess of Northumberland), inherited his entire estate. Lady Campden received the family seat of Titchfield, while the share which Lady Vaughan inherited was the domain of Stratton, also in Hampshire. Rachel remained with the Viscountess Campden at Titchfield for some time after their father's death. In 1669, Lady Vaughan married her second husband,
William, Lord Russell, who was three years her junior. They obtained a marriage licence at Titchfield on 31 July 1669, and were married on 20 August 1669. The marriage was described as having been happy, and Lord Russell appreciated his wife's intelligence, virtue, affection and piety. In 1678, upon the death of her childless brother-in-law, Francis, the couple became known as Lord and Lady Russell. Together they had four children: • Anne Russell (13 December 1671—April 1672) •
Rachel Russell (January 1674 – 28 December 1725), married
William Cavendish, 2nd Duke of Devonshire, by whom she had ten children. • Catherine Russell (23 August 1676 – 30 October 1711), married
John Manners, 2nd Duke of Rutland, by whom she had nine children. •
Wriothesley Russell, 2nd Duke of Bedford (1 November 1680 – 26 May 1711), married Elizabeth Howland, by whom he had six children. == Rye House Plot ==