The land that is now Land O' Lakes was taken from its Native American inhabitants in the 1830s as part of the
Second Seminole War. By the 1840s, a stage coach line ran through the center of where the CDP is now located. Eventually, by the early 1900s, a railroad line ran through the CDP and a station was built. Throughout the 20th century, Land O' Lakes expanded and absorbed surrounding communities such as Denham, Ehren, and Gowers Corner.
Dupree Gardens, one of Florida's original roadside tourist attractions, was located in what is now known as Land O' Lakes. The name Land O' Lakes was suggested and thought of in 1949. On September 1950, the community was renamed Land O' Lakes. ==Demographics==