During the initial Rage Virus outbreak in Britain, Don, his wife Alice, and four other survivors shelter in a cottage outside London. They hear a boy screaming and allow him inside, only to discover that a horde of Infected has followed him. As the Infected invade the cottage and kill the other survivors, Don urges Alice to leave the boy, but she refuses and is cornered by the Infected. Don flees and leaves on a boat. Twenty-eight weeks later, many Infected have died of starvation. US-led
NATO forces bring settlers into a protected zone in London. Don and Alice's two children, Tammy and Andy, arrive among the settlers and are housed on District One, a heavily guarded safe zone on the
Isle of Dogs. Tammy and Andy sneak out at dawn to their former home to retrieve family photographs and find Alice alive but ill. American soldiers capture the siblings and take them and Alice to an isolation unit, where the medical officer, Scarlet, discovers that Alice is an
asymptomatic carrier of the disease. Don, consumed with guilt, visits Alice, kisses her, becomes infected, and kills her. As the newly infected Don goes on a rampage and spreads the virus, Scarlet concludes that the siblings' genetic makeup may be important for developing a cure or vaccine and helps them escape. With infected and uninfected people difficult to distinguish, American troops are ordered to kill everyone. Doyle, a sniper, refuses to carry out the order and escapes with Scarlet and the siblings as the
US Air Force firebombs parts of London in an attempt to stop the spread. The group waits for a helicopter extraction arranged by Doyle's friend, Flynn, but Flynn insists on taking only Doyle. Doyle refuses to abandon the others, and they head toward
Wembley Stadium, where uninfected civilians have been ordered to assemble. They hide in a car as soldiers with
flamethrowers arrive, intending to kill anyone who might be infected. When the car will not start, Doyle attempts to push-start it and is burned alive. In the confusion, Scarlet, Tammy, and Andy escape into a dark
London Underground station. There, Don appears, kills Scarlet, and bites Andy. Tammy kills her father, but Andy becomes an asymptomatic carrier of the disease. Flynn finds the siblings and flies them to France. Twenty-eight days later, a voice on the helicopter radio, speaking with a French accent, requests help. The final shot then shows a horde of Infected emerging from the
Paris Métro and attacking
Paris. ==Cast==