Del Río began her career at
AD Torrejón in 1999 before moving to
Levante UD the following year. In her two seasons in
Valencia she won two doubles as Levante cruised through the
Superliga Femenina and the
Copa de la Reina. Del Río subsequently spent two seasons at
CE Sabadell and then returned to Levante, where she remained for the next four years, winning an additional League in 2008 and two more Cups. In 2008, she left Levante to play abroad for the first time, playing in the
W-League for
FC Indiana. She scored 33 goals in her two years in the W-League, making it into the All-League team. In summer 2009 she signed for European powerhouse
1. FFC Frankfurt. Starting the season as a reserve, she made herself a place in the starting eleven for a few weeks after scoring in three consecutive games coming from the bench. Overall, she scored six goals in just ten matches in the
Bundesliga, as she left Frankfurt in December to sign for
Boston Breakers, marking her
Women's Professional Soccer debut. For the
2011 season she transferred to
Philadelphia Independence, with whom she reached the championship play-offs. In the final she missed the team's final penalty to finish runners-up. Del Río joined English
FA WSL club
Bristol Academy in 2012. Under coach
Mark Sampson the club finished second in the
2013 FA WSL and were losing finalists in the
2012–13 FA Women's Cup. In January 2015 Bristol confirmed that del Rio had left the club after scoring 14 goals in 47 games. She continued her career in Spain, with ambitious
Segunda División club
CD Tacón, signing for
Madrid CFF a year later. ==International career==