Papadopoulos began his professional career playing with the Greek club
Iraklis, in the 1996–97 season. After five years with Iraklis, he signed to play with the
Greek League powerhouse
Panathinaikos in 2001, and he stayed there until 2003. He then returned to Iraklis the following season, and stayed there for only one year, before next signing with the Russian club
Dynamo Moscow, in the year 2004. In 2007, he joined the
Spanish ACB League club
Real Madrid. In 2008, he joined
Fortitudo Bologna of the
Italian League. He won the
EuroLeague championship during the
EuroLeague 2001–02 season, while he was with
Panathinaikos, and also the
EuroCup championship, while he was with
Dynamo Moscow, in the year 2006. In 2007, his performance with
Dynamo Moscow during the
EuroLeague 2006–07 season, earned him a selection to the
All-EuroLeague Second Team. He joined the Greek club
PAOK Thessaloniki for the 2009–10 season, and donated his salary to charity. In February 2011, he joined the Russian club
Khimky Moscow Region. In August 2011, he signed a one-year deal with
Olympiacos. With Olympiacos, he won the EuroLeague championship in
2012. On 5 September 2012, he returned after few seasons to his former club PAOK. On 6 February 2014, Papadopoulos went back to Spain, after signing with
1939 Canarias. After only one game played, he parted ways with them. ==National team career==