In 1899, a terrorist group led by the "
Fantom" robs the
Bank of England for
Leonardo da Vinci's blueprints of
Venice's foundations, kidnaps
German scientists, and destroys a
Zeppelin factory in Berlin. With the
British and
German Empires threatening to start a world war, a British emissary named Sanderson Reed travels to
Kenya Colony to recruit retired adventurer and hunter
Allan Quatermain. He initially refuses until assassins attempt to kill him. After defeating them, he agrees. In
London, Quatermain meets Reed's boss "
M", who explains that the Fantom intends to profit from the world war and is going to attack the world's leaders at a conference in Venice in three days. To prevent this, M forms the
League of Extraordinary Gentlemen and recruits Quatermain,
Captain Nemo,
vampire scientist
Mina Harker, and invisible thief
Rodney Skinner. The League travels to the
London Docklands to recruit
Dorian Gray, Mina's former lover, who is immortal due to a missing cursed portrait. The Fantom and his assassins attack the League, but
U.S. Secret Service Agent
Tom Sawyer intervenes and helps them fend off the attack, forcing the Fantom and his men to retreat. Sawyer then reveals he was sent by the U.S. to join the effort to stop the Fantom. After he and Gray join the League, they capture
Edward Hyde in
Paris, who transforms back into his alter ego
Dr. Henry Jekyll, who also joins the League after being offered amnesty for his crimes. While traveling to Venice in Nemo's submarine, the
Nautilus, Jekyll experiences trouble controlling Hyde while the other Leaguers deduce a
mole is on board after discovering a camera's
flash powder residue in the wheelhouse and someone stole a vial of Jekyll's transformation formula. Suspicion falls on Skinner, but he is nowhere to be found. The
Nautilus arrives in Venice as several hidden bombs detonate, causing the city to collapse. Sawyer uses one of Nemo's automobiles to signal him to launch a missile at a key building to stop the destruction, while Quatermain confronts the Fantom, who is unmasked as M before escaping again. Dorian shoots Nemo's
first mate Ishmael and steals the
Nautilus exploration pod, but Ishmael successfully warns the League of his treachery before dying. While pursuing Dorian, the League uncover a
phonograph recording that Dorian left revealing M stole Dorian's painting to enlist his aid in manipulating the League to gain Quatermain's help in capturing Hyde, a skin sample from Skinner, Mina's blood, Jekyll's formula, and photos of Nemo's science while an inaudible audio frequency activates several bombs hidden aboard the
Nautilus. Jekyll and Hyde join forces to drain the flooded sections while Skinner secretly messages the League, informing them he snuck aboard the exploration pod. Using Skinner's directions, the League reaches northern
Mongolia and locates M's mountain fortress. They soon regroup with Skinner, who reveals M took the kidnapped scientists' families hostage to force them to mass-produce M's work, and he intends to sell a sample case to competing nations. The League split up, with Nemo and Hyde rescuing the scientists and their families, Skinner planting bombs to destroy the fortress, Mina fighting and killing Dorian with his painting, and Quatermain and Sawyer working to capture M, who Quatermain deduces is
Professor James Moriarty. Nemo and Hyde complete their task, but are overwhelmed by M's henchman, Dante, after he overdoses on Hyde formula until Skinner's bombs detonate, killing Dante while the pair escape. Quatermain corners M, but an invisible Reed takes Sawyer hostage. Quatermain kills Reed, but M fatally stabs Quatermain before Sawyer kills him in turn. Quatermain dies, wishing Sawyer luck in the new century. As the League ensures Quatermain is buried in Kenya, they recall how a
witch doctor promised that Africa would never let him die. Nemo offers The League a home on the Nautilus; they agree to be more conspicuous. The witch doctor performs a fiery ritual that summons an unnatural thunderstorm over Quatermain's grave. == Cast ==