; : :The main protagonist of the series. Above all else, Kazahaya does not want to die - a fact which seems to be linked to a girl from his past named Kei, his twin sister. In his thoughts, he has indicated that he and Kei lived a secluded life, effectively trapped on a single property where no other children lived, and also indicates that neither he nor Kei ever finished their schooling even at the elementary level. :At the very start of the series, Kazahaya is found lying in the snow, having apparently run away from his former home and very nearly freezing to death, before being found by Rikuo, who brings him back to the Green Drugstore. Since then, he has always been trying to earn money so that he might live alone, which is the main reason why he accepts the 'extra' jobs offered by Kakei. He has a supernatural power which is something like
psychometry in that he can see the "memories" of things or persons when he touches them; he may also possess some
empathic ability as he seems capable of absorbing emotions as well as memories, and on at least one occasion has
channeled the present visual perspective of another person (Rikuo). :While at times he may seem rather helpless, or at least hopelessly naive, he has many skills and abilities which make him highly capable in certain tasks. Specifically, some of his behaviors and abilities seem remarkably similar to a cat, including a heightened sense of smell and vision, several demonstrations of cat-like agility and speed, and his tendency to look like an angry kitten when upset. Kazahaya is noted to be seventeen-years-old at the start of the series, and is smaller, slimmer and has a much more feminine appearance than Rikuo, to the point that he can be accurately described as "pretty". He gets emotional easily, and frequently plays into Rikuo's hands when teased due to his quick temper. :In
Drug & Drop, it's revealed that he is related by blood to Shuichiro Kudo from
Wish and that their family is a very powerful one. ; : :The second protagonist of the series, Rikuo is Kazahaya's current co-worker and roommate, as well as the one who found Kazahaya lying nearly dead in the snow. Similarly to Kazahaya, his mysterious past is also centered on a woman, this one named Tsukiko. It appears that they lived together at some point, though at present the exact nature of their relationship remains unknown. Rikuo often comes across as being cold and insensitive, sometimes even sarcastic, and takes great pleasure in teasing Kazahaya. However, in spite of his nature, he is always the one who comes to Kazahaya's rescue when certain jobs go wrong. He has powers similar to
telekinesis, as he can break things like cups, locks and branches. :Kazahaya claims that he and Rikuo are the same age, meaning Rikuo is also 17. Of the two protagonists, Rikuo is much calmer and quieter, and in appearance is taller and more
masculine - high-school girls appear to come to the store often specifically to ask Rikuo where some random item is as an excuse to talk to the handsome boy. Rikuo has tattoos on his right shoulder and back, which has been implied to have a connection to Tsukiko. An interesting quirk about Rikuo is that he likes sweet things such as chocolate, which is considered unusual and un-masculine in Japanese society. ; :The owner of the Green Drugstore, Kakei is the one who sends the two boys out on missions, usually without telling them everything first. He seems to know exactly how things will turn out due to his power of precognition, however it has been noted that this power cannot be used on someone more powerful than himself, as in the case of his failures to find Tsukiko for Rikuo. :Kakei is a very beautiful person and has a gentle, kindly air about him. However, he is also very mysterious, and his expression often changes quickly from gentle and kindly to
eerie and perhaps even dangerous. He is also noted to have a cruel, and even
sadistic side to his nature, although this side of his personality is mostly actualized in almost-subtle teasing. It turns out that the reason he opened the Drugstore is in order to protect Kazahaya and everyone he cares about. :It is later revealed that Kakei and Saiga's true forms are Hisui and Kokuyo from
Wish, but many years after the events that took place in that story. ; :Saiga is often seen hanging around in the Green Drugstore - usually napping, smoking, or both. He also always wears a pair of dark sunglasses which he never seems to take off. While it is unknown whether he has any supernatural powers like the rest of the cast, it was mentioned that he is extremely good at pickup souls, finding people, and is currently working on helping Rikuo find Tsukiko. He is Kakei's lover and is skilled in
domestic areas, such as sewing and making food.
Minor characters ; :Kei is Kazahaya's sister and not much is known about her, although Kazahaya mentioned that she has "cat-like" qualities. The reason Kazahaya left her has not yet been clarified; his only explanation is a guilty, "But if we had stayed together, it would have been either you or me." It is revealed in Drug and Drop that she can see the future of objects by touching them, similar to Kazahaya's ability to see the past. ; :Tsukiko is a woman from Rikuo's past who has gone missing. It is thought she may be dead as when she went missing Rikuo found her room "all splattered with blood". In recent chapters it is clarified that Tsukiko is Rikou's elder sister, and also his only living blood relative. She appears in one of Kazahaya's dreams and speaks to him, suggesting an ability to enter dreams. She can also see the future, albeit only a day or so ahead. ; :Satoru is a student at an all-boys private school. He is Vice President on the student-body government and was a victim of attempted
rape. Unbeknown to his classmates and himself, he has the ability to project a piece of his soul out of his body in order to fulfill the desires of his
subconscious. ==Crossover with other CLAMP works==