The LEM domain is a conserved protein motif present in multiple inner nuclear membrane proteins that play roles in nuclear structure and function. This approximately 40-amino acid region enables proteins to bind the barrier-to-autointegration factor (BAF), tethering repressive chromatin and regulating genome organization at the nuclear periphery. LEM domain-containing proteins are important for nuclear envelope integrity, chromatin architecture, and gene expression control, with disruptions implicated in diverse human diseases known as laminopathies.