On 1 February 2019, Machado announced she would run for president if
Juan Guaidó were to call elections, owing to the
2019 Venezuelan presidential crisis. For the
next Venezuelan presidential election, Machado was recognized as a front-running opposition candidate. In an interview discussing the election, Machado insisted that she was not interested in the opposition primary and said that "my goal is to get Maduro out and be able to defeat the regime using all the force". She argued: "There are only two options here ... We win with a huge majority or Maduro steals the election." According to head of the Delphos pollster Félix Seijas, "[t]he opposition as it existed is no longer, and that opens the door for her to capture support beyond her radical base", while explaining her expanded support. On 30 June 2023, she was disqualified from holding office for 15 years by the government due to her leadership in anti-government protests. Following the escalation of government pressure against opposition figures, Machado was barred from holding public office and subjected to restrictions on her movement. During the primaries, Machado positioned herself against the technical assistance of the
National Electoral Council (CNE) in the election, alleging that CNE is part of a "criminal system". In the same way, she defended the return to manual voting. On 15 March 2023, she officially began her campaign tour of the country, in the state of
Mérida. During her pre-campaign, Machado maintained criticism towards the traditional opposition leadership, mainly the
Democratic Action,
Justice First,
A New Era, and
Popular Will parties. She made it clear that she was willing to negotiate an exit from
Chavismo to achieve a transition. On 30 June 2023, Machado was disqualified for fifteen years by the comptroller general of Venezuela after a request from the politician
José Brito. The comptroller linked her to alleged crimes by
Juan Guaidó and accused her of supporting
sanctions during the Venezuelan crisis. Analysts determined that the accusation of having participated in the interim was incoherent, taking into account that she was not a member of the 2015 opposition National Assembly (being prevented by a disqualification from the Comptroller's Office), in addition to never having been appointed in any position in Guaidó's interim government. The
United Nations, the
Organization of American States, the
European Union and numerous countries condemned Machado's disqualification. The
European Parliament called the ban "arbitrary and politically fabricated", and the Associated Press noted that banning opposition politicians from elections was a frequent tactic used by the government. Machado's 15-year disqualification was confirmed by the
Supreme Tribunal of Justice in January 2024. The court said the disqualification was "for being involved... in the corruption plot orchestrated by the usurper Juan Guaido", which had led to a "criminal blockade of the Bolivarian Republic of Venezuela, as well as the shameless dispossession of the companies and wealth of the Venezuelan people abroad, with the complicity of corrupt governments". Machado named
Corina Yoris as her alternate. Yoris was unable to register as a candidate and
Edmundo González Urrutia was chosen as her replacement.
2024 presidential election in 2024 Although Machado was not the presidential candidate in the
2024 Venezuelan presidential election, she remained the leader of the
opposition to Chavismo during the electoral process. The majority support that candidate
Edmundo González received in various polls was due to the boost given to him by Machado's support. Regarding the role that Machado would play in a González Urrutia government,
The Telegraph commented: "Should the opposition win, Ms Machado is widely expected to be the de facto leader of a government formally led by Mr González." The newspaper compared the massive popular movement around Machado with the rise of Hugo Chávez to the presidency in 1998, in terms of the "fervor" it generated in citizens, in a context of both political crisis and systemic decadence. The event, which was planned to be a caravan from Chacaíto to El Marqués, became a march with the attendance of dozens of thousands of people.
The New York Times described Machado as "an energetic former legislator whose central message is the promise of bringing Venezuelans home by restoring democracy and getting the economy going again". Following the Venezuelan government's announcements of falsified election results, a
national and international political crisis developed. On 1 August, Machado published a letter in
The Wall Street Journal, stating that she had gone in to hiding "fearing for my life, my freedom, and that of my fellow countrymen from the dictatorship of Nicolás Maduro"; in the letter, she laid out the evidence she said she had from the vote tallies supporting the opposition win, and stated that Maduro had expelled witnesses from the polls, while the witnesses "protected the voter receipts with their lives throughout the night" of the elections. On 9 January 2025, government forces attempted to arrest Machado after a rally in
Chacao,
Caracas, where she had reappeared publicly after three months in hiding. According to reports, government troops "violently intercepted" her vehicle and shot at the motorcycles carrying her. After Nicolás Maduro was
detained by US forces on 3 January 2026, opposition leader Machado called for
Edmundo González, whom the opposition claim had won the 2024 presidential election, to assume the presidency, to which he responded that he was "ready to rebuild our nation" and that the coming hours would be "decisive".
After 2026 United States intervention in Venezuela Following the
United States capture of Nicolás Maduro and Vice President
Delcy Rodríguez assuming the interim presidency, several U.S. lawmakers have called for the Venezuelan opposition party to take power with Machado at the helm. U.S. president Donald Trump has been dismissive of Machado, while U.S. secretary of state
Marco Rubio spoke favorably of her, but stated that, with the majority of Venezuela's opposition leaders currently absent from the country, it was too early for such a transition. On 12 January, Machado held an unscheduled meeting with
Pope Leo XIV at
Vatican City. According to a statement shared on
Twitter by her party,
Vente Venezuela, the discussion focused on seeking the pope’s assistance in advocating for the release of all
political prisoners in Venezuela. Machado also met with
Cardinal Secretary of State Pietro Parolin. On January 15, 2026, Machado met privately with Trump and later with multiple U.S. senators. Machado has plans to go back to Venezuela as soon as possible. She said that "This has nothing to do with tension or relations between Delcy Rodriguez and myself," and discussed that the "criminal structure" that has dominated Venezuela for years would eventually dismantle itself. On 20 January 2026, she was received at the headquarters of the
Organization of American States (OAS) to meet with general secretary
Albert Ramdin. The OAS held a meeting to discuss the situation of the
political prisoners in Venezuela. On 26 January, after a hearing on Venezuela on the US Senate, US secretary of state Marco Rubio met with Machado. She later said to reporters that a change in Venezuela was coming. In an interview of
NBC, Delcy Rodríguez said about Machado that “She will have to answer to Venezuela why she called upon a military intervention, why she called upon sanctions to Venezuela, and why she celebrated the actions that took place at the beginning of January.” At Machado's request, she met for a second time with Donald Trump in the White House on 6 March to review plans for her trip to come back to Venezuela. In March 2026, Machado travelled to Chile for the inauguration of Chilean president
José Antonio Kast and to meet other political leaders including King
Felipe VI of Spain. Machado initiated a demonstration in
Santiago of over 17000 people. She called for political change in Venezuela and promised to work toward conditions that would allow migrants to return home safely. Machado said her own return to Venezuela will occur later in coordination with allies. == Political views ==