The song received favorable reviews from many music critics. Steve Huey from
AllMusic called it a "playful safe-sex anthem".
Larry Flick from
Billboard magazine stated that the "hot rap divas show no sign of cooling off with this spicy hip-hopper that pokes fun at people with inhibitions about sex." He remarked that "cheeky rhymes and charming demeanors make this yet another multiformat winner." DeVaney and Clark from
Cashbox commented, "Although they have changed their style from their original hip-hop image to commercial/R&B/Rap, the sound of this single is quite catchy and will probably take R&B by storm." They also concluded, "This single, by far, is one of the most commercial rap cuts of the year." David Thigpen from
Entertainment Weekly described it as "an articulate, funny, and danceable primer on sex and the single flygirl that hit male-dominated hip-hop where it hurt." A reviewer from
Melody Maker wrote, "It's one of the most uncompromising safe sex raps ever written. The song also recoginises the biological differences between males and females, and the serious messages are balanced by a cheeky, never ribald, sense of humour. Their concern is genuine. It is, as they say, largely about understanding." Kim France from
Spin felt that "Let's Talk About Sex" "packs a wallop with the kind of sassy, seducto-humor the two previous Salt-N-Pepa records were chock full of." ==Music video==