The humans •
Brandy Carter – A beautiful animal
psychiatrist. Her appearance is based on that of actress
Lynda Carter,
Bettie Page, and women Cho was attracted to in his youth. •
Frank Melisch – A nerdy
veterinarian. Frank is in love with Brandy but afraid to tell her. •
Tony – An accident-prone maintenance man. •
Julius – The owner of Liberty Meadows animal sanctuary and an avid fisherman. •
Jen – Brandy's roommate, a sexy rocket scientist who enjoys toying with men. •
Al – Owner of Al's Treetop Tavern, the local bar where many of the other characters hang out. An educated man and believer in various
conspiracies. •
Roger – Brandy's ex-fiancé who's trying to win her back. •
Barbara Carter – Brandy's controlling, malevolent mother. She hates Frank, and is constantly scheming to fix Brandy up with Roger. •
John Carter – Brandy's doting father. The complete opposite of Brandy's mother. •
Evil Brandy – Brandy's
evil twin from a
mirror universe. A megalomaniacal criminal mastermind. In volume 3, she tied up Brandy, duct-taped her mouth shut, and shoved her in a closet in an attempt to impersonate her and kill Frank. •
Alternate Frank / "Ace" – Frank's super-studly twin from a mirror universe. The most feared lawman in the world and Evil Brandy's nemesis.
The animals •
Ralph – A midget circus bear with a perpetual squint and a penchant for inventing dangerous gadgets. •
Dean – A former fraternity house mascot rescued by Brandy, Dean is a lecherous, sexist pig with a drinking problem and an addiction to cigarettes. Dean is at the clinic for detox but keeps breaking the rule forbidding smoking. A recurring segment has him hitting on various women in bars, only to have them beat him for his boorishness. •
Leslie - A dim-witted frog with
hypochondria, and Ralph's friend. •
Truman – A cute, naive young duck who always addresses the humans as "sir" and "ma'am." •
Oscar – A mischievous
dachshund and Truman's best friend. Oscar is the only animal in the strip who is not anthropomorphized, and does not speak aside from typical canine vocalizations. •
The Cow – A psychotic villain who suffers from
mad cow disease. •
Khan – A giant catfish who serves as Julius' constant nemesis. He appears in strips that depict the characters fishing. •
Mike – A raccoon with
obsessive–compulsive disorder.
The author •
Frank Cho, aka "Monkey Boy" – Creator of the strip. Appears in the strip as a chimpanzee to break the
fourth wall. ==Collected editions==