•
Louis "Louie" Anderson (voiced by
Louie Anderson) — Based on Anderson's younger self. Louie is an 8-year-old, living in the fictional town of Cedar Knoll,
Wisconsin. He is a very sensitive, humorous, impressionable, and intelligent young boy. He often uses his gifted sense of humor to deal with difficult situations. He always stands up for his rights and principles, but also for those of others. His most notable catchphrase in the series is "All right!" •
Jeannie Harper (voiced by
Debi Derryberry) — Louie's best friend. She often defends Louie from local bullies. Louie has a crush on her. •
Michael "Mike" Grunewald (voiced by
Justin Shenkarow) — Louie's friend with a sarcastic sense of humor. He has a somewhat relaxed attitude and comes from a rather wealthy family, sometimes much to Louie's jealousy. •
Toddler Tobolinski — Louie's other friend. He is somewhat shorter than the others, about the same height as Louie, and loves activities like recess. •
Scott Jensen — One of Louie's friends. He appears quite often in the first and third seasons, but is rarely seen in Season 2. •
Andrew "Andy" Mortimer Anderson (voiced by Louie Anderson) — Louie's demanding, but caring father. He is a veteran of
World War II and likes to tell his family stories about his experience at the front in
Europe. Much of the humor regarding Andy involved his comic superiority complex and equally comical unawareness of his limitations. Though he often appeared out of touch with reality, Andy was secretly a very gifted
chess player, a skill Louie was briefly shown to have himself, but he exposed his gift during the latter half of his life because of the way he was supposedly mistreated for it in his youth (including during the time he had previously served in the army; even going so far as to disguise himself at chess tournaments so he would not be recognized). He is a proud owner of a
Rambler sedan (most probably a 1959 Rambler Six), which appears on the show in various episodes. His catchphrases: "For crying out loud!" and "I heard that." Despite his appearance, he is a very caring and loving, with his family, neighbors (to whom he is seen expressing solidarity in times of trouble), and other characters. •
Ora Anderson (voiced by
Edie McClurg) — Louie's kind, loving, and sweet-natured mother. She usually acts as the voice of reason for Louie and Andy and also for Tommy. •
Thomas "Tommy" Anderson (voiced by
Miko Hughes) — Louie's youngest brother. Louie teases him a lot in the beginning. •
Glen Glenn (voiced by Justin Shenkarow) — The local bully of Louie's school who teases Louie and the other kids. His mother
Jen Glenn has a hot temper and loud voice, which the other citizens of Cedar Knoll do not like. •
Craig Eric, Paul George — Glen Glenn's friends and other bullies. •
The Melvins — A group of chess specialists. One of them is actually named Franklin, but is still called Melvin. •
Henrietta Shermann (voiced by
Mary Wickes) — The mother of Ora and maternal grandmother of Louie. When her voice actress Mary Wickes died in Season 2, the producers elected to make an episode where Louie handles the death of his grandmother. •
Pepper — Louie's obese pet
goldfish. •
Sid Anderson, John Anderson, Danny Anderson, Peter Anderson — Louie's older brothers. •
Norton Jensen, Earl Grunewald, Gus Williams, Mrs. Stillman — Louie's neighbors. •
Laura Anderson, Carol Anderson, Charlie Anderson, Julie Anderson — Louie's older sisters. ==Episode list==