Upon completing her formal education, McDermott began teaching physics full time at City College before moving to the
University of Washington (UW) with her husband for a post-doctoral position. Although her husband was granted a faculty position, she was unable to join him due to anti-nepotism rules. She sought employment at
Seattle University before the rules were struck down and she joined the Department of Physics at UW. In the early 1970s, McDermott established the Physics Education Group (PEG) to "improve the teaching and learning of physics from kindergarten all the way through graduate school." The PEG was the first research group in the United States where students could earn a physics PhD with a research concentration in the teaching and learning of physics. McDermott led the PEG in studying student reasoning and misconceptions in physics. This work resulted in the development of the
Tutorials in Introductory Physics, as well as a curriculum for future teachers titled
Physics by Inquiry. == Awards and recognitions ==