Humphreys turned professional at the start of June 2021, at 19 years old, having had to postpone it a year due to the
COVID-19 pandemic as the LPGA and LET Q-schools were cancelled. After two starts on the
Ladies European Tour she sealed her maiden professional win in just her third professional start and first on the
LET Access Series, securing a six-shot victory at the
Golf Flanders LETAS Trophy. She continued to win the
2021 LETAS Order of Merit, securing a Ladies European Tour card for
2022. In August 2021, Humphreys played four weeks in a row on the
Nordic Golf Tour in Sweden as part of the LETAS' Nordic Swing, finishing second in the last three of the events, which earned her the
2021 season Order of Merit win. In March 2023, Humphreys began the final day six shots behind overnight leader
Moa Folke at the
Joburg Ladies Open, but fired a final round of 67 (–6) to secure a two-shot victory and her maiden LET title. ==Amateur wins==