After the outbreak of
World War I, Mebane became the Rockingham County Committee Chairwoman of the North Carolina Division of the Woman's Committee of the
Council of National Defense. In 1922, she was awarded the Cross of Mercy by the
King of Serbia for her "support of the sick, wounded, prisoners of war, refugees, children of the men killed in the war, and aged war mothers." Mebane and her husband were registered members of the Conference for Education in the South. In 1930 she organized the first public library in Rockingham County. In 1930, she was considered the "first woman ever to seek public office in Rockingham County" when she filed as a candidate. In 1931, Lily Morehead Mebane was elected to the North Carolina state legislature. She served two terms, after being re-elected in 1933, and chaired the Committee on Public Welfare in the state house of representatives. As a house representative, she advocated for legislation affecting state roads, divorce laws, education, child labor laws and pensions for Confederate veterans and war widows. Due to her life in public service, she was dubbed the "First Lady of Rockingham County." In 1934, Mebane ran an unsuccessful campaign for a
U.S. Congressional seat. She was unanimously endorsed by both the North Carolina House of Representatives and the
North Carolina Senate to succeed her brother as the American Minister to Sweden. Had she been selected, Mebane would have been the first American woman ambassador to Sweden. Ultimately, President
Franklin D. Roosevelt did not appoint her to the position. == Personal life ==