Main •
Russell Hornsby as Lincoln Rhyme, a brilliant but hardheaded forensic criminologist who suffers near-fatal injuries while on the job, leaving him a
tetraplegic. He nevertheless continues his work remotely, working with others to solve cases. •
Arielle Kebbel as Amelia Sachs, an intuitive rookie NYPD officer who becomes Lincoln's most trusted ally in the hunt for the Bone Collector. • Roslyn Ruff as Claire, Lincoln's caregiver and assistant • Ramses Jimenez as Eric Castillo, an NYPD detective and Sellitto's new partner •
Brooke Lyons as Kate, a forensic scientist who worked with Lincoln during his time on the force •
Tate Ellington as Felix, a computer expert working with the team who is quick to speak his mind •
Courtney Grosbeck as Rachel Sachs, Amelia's teenage sister •
Brían F. O'Byrne as Peter Taylor / The Bone Collector, a serial killer Lincoln has chased for his entire career who reemerges to complete what he considers unfinished business between the two. •
Michael Imperioli as Rick Sellitto, a veteran NYPD detective and Lincoln's former partner
Recurring •
Claire Coffee as Danielle Taylor, the wife of the Bone Collector •
Tawny Cypress as Naia, Lincoln's ex-fiancée • Jaidon Walls as Camden Rhyme, Lincoln's son
Guest • Rosa Evangelina Arrendondo as Chief Olsen, the chief of police •
Tracie Thoms as FBI Agent Cutter, an FBI Agent who was Lincoln's former supervisor in the NYPD ==Episodes==