New York Giants 2010 season Joseph was selected by the
New York Giants with the 46th overall pick in the second round of the
2010 NFL draft. He signed with the Giants on July 31, 2010. Joseph was inactive in 10 games as a rookie in 2010 and only played in six games. He played his first NFL game against the
Chicago Bears in Week 4, and was credited with a tackle in the game. On December 26, he had a season-best five solo stops versus the Packers. Joseph finished his first season as a Giant with eight combined tackles, six of them solo.
2011 season Joseph was moved into a full-time starter role in his second year, starting 15 games and playing in all 16 contests. On October 30, he notched his first career sack on
Miami Dolphins quarterback
Matt Moore. In Week 13, he had a season-high nine solo tackles in the Giants' loss to the Packers. Joseph continued to start in the playoffs and had three tackles in each of the opening two playoff games of the Giants' postseason. He followed it up with a two-tackle performance with an added pass deflection. Joseph started in Super Bowl XLVI and garnered two tackles as the Giants defeated the Patriots by a score of 21–17. On their run, they held the
Atlanta Falcons,
Green Bay Packers,
San Francisco 49ers and
New England Patriots to an average of 14 points per game.
2012 season On October 21 against the
Washington Redskins, he forced a fumble and recovered it, helping the Giants prevail over the Redskins 27–23. In Week 8 against the
Dallas Cowboys, Joseph had two sacks as his team's defense picked up a total of four sacks of
Tony Romo and forcing six turnovers, as the Giants won the game 29–24. In the 2012 season, Joseph started all 16 games for the Giants for the first time in his career, recording a career-high 59 tackles that ranked fifth on the team while also posting four sacks and a forced fumble.
2013 season In the Giants' Week 3 loss against the
Carolina Panthers, he posted a season-high eight tackles. He missed the
Philadelphia Eagles game with an injury in Week 5. On December 15, he notched seven tackles and a sack against the eventual
Super Bowl champion
Seattle Seahawks. Joseph finished his last season as a Giant with 59 tackles, three sacks, and a forced fumble in 15 starts.
Minnesota Vikings On March 11, 2014, Joseph signed a five-year, $31.5 million deal with the
Minnesota Vikings, including a $3 million signing bonus, $12.5 million guaranteed, and an average annual salary of $6.25 million. In 2015, Joseph will earn a base salary of $3.9 million and a workout bonus of $100,000. Joseph has a cap hit of $4.6 million while his dead money value is $6.1 million.
2014 season Joseph was one of nine people who were shot by a gunman inside the Minneapolis nightclub 400 Soundbar on August 11, 2014. A stray bullet struck him in the calf. The Vikings characterized the injury as "minor." In Joseph's first regular season game with his new team, he was credited with five tackles and a sack in the Vikings' 34–6 victory on the road against the
St. Louis Rams. Joseph finished the 2014 season with three sacks, 47 total tackles, and one pass defensed in 16 games and starts.
2015 season Joseph was named the NFC Defensive Player of the Week after his performance in the Vikings 21–18 overtime win over the Rams in Week 9. Joseph was credited with ten tackles (seven solo), 0.5 sacks, three tackles for loss, and two pressures in the victory. The 10 combined tackles tied for the most by a defensive tackle in a game this season. Joseph became the first Viking defensive tackle to win the award in over a decade (the last was
Kevin Williams in 2004) and first Viking defender to receive the honor since linebacker
Anthony Barr in 2014. He was ranked 76th by his fellow players on the
NFL Top 100 Players of 2016.
2016 season In the Vikings' Week 1 win over the
Tennessee Titans, Joseph contributed with five tackles and sacked quarterback
Marcus Mariota for a 9-yard loss in the second half of the 25–16 victory. Joseph finished third on the team in total tackles with 77, tied his career high with four sacks, and added seven tackles for loss and three forced fumbles. Joseph became the fifth Vikings defensive tackle to have at least 100 tackles and 4.0 sacks in a season, joining
Alan Page,
James White,
Charlie Johnson and
Henry Thomas. On January 12, 2017, Joseph was selected to his first
Pro Bowl as an injury replacement for
Aaron Donald of the
Los Angeles Rams, becoming the first Vikings defensive tackle to be selected since
Kevin Williams in 2010.
2017 season On August 5, 2017, Joseph signed a four-year, $50 million contract extension with the Vikings with $31.5 million guaranteed. He started all 16 games, finishing second in the league among defensive tackles with 68 tackles. On January 22, 2018, Joseph was named to his second straight Pro Bowl. He was ranked 83rd on the
NFL Top 100 Players of 2018.
2018 season In Week 5 against the Eagles, Joseph scored a 65-yard touchdown off a fumble recovery. This was the first touchdown of his NFL career. Joseph finished the 2018 season with 58 tackles, one sack, and one forced fumble.
2019 season In the 2019 season, Joseph finished with three sacks, 44 total tackles, and one forced fumble in 13 games and starts. Joseph was released on March 13, 2020.
Los Angeles Chargers On March 30, 2020, Joseph signed a two-year, $17 million contract with the
Los Angeles Chargers. In the 2020 season, Joseph appeared in and started all 16 games. He had 62 total tackles on the year. In the 2021 season, Joseph appeared in 14 games, of which he started 12, and had 57 total tackles and one sack.
Philadelphia Eagles On November 16, 2022, Joseph agreed to a one-year deal with the Eagles. Joseph appeared in eight regular season games for the Eagles in the 2022 season. He had 20 total tackles and .5 sacks. During the first quarter of the 2022 season
NFC Championship, Joseph recovered a key fumble forced by linebacker
Haason Reddick, a play which led to significant injury of the arm of 49ers quarterback
Brock Purdy. The Eagles lost
Super Bowl LVII to the
Kansas City Chiefs 38–35.
Buffalo Bills On November 2, 2023, Joseph signed a one-year deal worth up to $3.72 million with the
Buffalo Bills. He played in seven games and had one sack in the 2023 season.
Dallas Cowboys On August 27, 2024, Joseph signed with the
Dallas Cowboys on a one-year contract worth $2.5 million. In the 2024 season, he finished with two sacks, 19 tackles, and one forced fumble. ==Career statistics==