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Management of post-traumatic stress disorder

Management of post-traumatic stress disorder refers to the evidence-based therapeutic and pharmacological interventions aimed at reducing symptoms of post-traumatic stress disorder (PTSD) and improving the quality of life for individuals affected by it. Effective approaches include trauma-focused psychotherapy as a first-line treatment, with options such as cognitive behavioral therapy (CBT), prolonged exposure therapy, and cognitive processing therapy (CPT) demonstrating strong evidence for reducing PTSD symptoms.

Psychotherapy
Evidence-based, trauma-focused psychotherapy is the first-line treatment for PTSD. Psychotherapy is defined as a treatment where a therapist and patient build a therapeutic relationship and focus on the patient's thoughts, attitudes, affect, behavior, and social development to lessen the patient's psychopathologies and functional impairment. Cognitive behavioral therapy Cognitive behavioral therapy (CBT) focuses on the relationship between someone's thoughts, feelings, and behaviors. It helps people understand the discrete nature of their thoughts and feelings, and to be better able to control and relate to them. It began with the work of American psychologist Albert Ellis in the late 1950s, and was notably expanded on by American psychiatrist Aaron Beck. CBT involves exposure to the trauma narrative in a controlled way to reduce avoidance behaviors related to the trauma. Education about the effects of trauma and stress management techniques are common aspects of CBT. There is evidence that CBT combined with exposure therapy can reduce PTSD symptoms, lead to a loss of PTSD diagnosis, and reduce depression symptoms. The most applicable techniques vary from person to person, with no current front-runner showing any particular advantage over the other. Trauma-focused cognitive behavioral therapy Trauma-focused cognitive-behavioral therapy (TF-CBT) was developed by Anthony Mannarino, Judith Cohen, and Esther Deblinger in the mid-1990s to help children and adolescents with PTSD. Individuals work through the memories of the trauma in a safe and structured environment, trying to correct negative cognitions and thoughts while also performing gradual exposure to triggers. This therapy is held over 8 to 25 sessions with the child/adolescent and their caregiver. The treatment helps correct distorted beliefs in the children while also helping parents and caregivers process their own distress and support the children. Cultural adaptations may rely on targeting the unique experience of a group, such as chronic exposure to racial trauma, or culture-specific coping strategies, such as including racial socialization and community support. In recent years, psychologists have tested the effectiveness of culturally modified TF-CBT approaches with different communities, such as unaccompanied child migrants and women in war-torn countries. Research suggests that cultural adaptations to TF-CBT can improve intervention effectiveness. and the National Institute of Clinical Excellence (NICE). The Australian Psychological Society considers it a Level I (strongest evidence) treatment method. developed a cognitive model that explains what prevents people from recovering from traumatic experiences and thus why people develop PTSD. The model suggests that PTSD develops when individuals process the traumatic event in a way that makes them feel that there is serious current threat. This perception of a threat is followed by reexperiencing arousal symptoms and persistent negative emotions like anger and sadness. Differences in how the individual appraises the event ("I cannot trust anyone anymore" or "I should have prevented what happened") and the poor integration of the most intense moments of the trauma into memory contribute to the distorted way people with PTSD make sense of what happened to them. Ehlers, Clark and others developed a cognitive therapy based on this model, the details of which were first published in 2005. It is a form of cognitive behavioural therapy that involves developing and believing a new, less threatening understanding of the trauma experiences. Patients gain an increased understanding of how they perceive themselves and the world around them, and how these beliefs motivate their behavior, before beginning the process of changing these thought patterns. Thus, three goals drive cognitive therapy for PTSD: • Modify negative appraisals of the trauma • Reduce reexperiencing symptoms by discussing trauma memories and learning how to differentiate between types of trauma triggers • Reduce behaviors and thoughts that contribute to the maintenance of the "sense of current threat" One specific practice is imagery rescripting where the therapist guides the patient to reimagine their traumatic memory in a way that gives them control so that they can create new outcomes. For example, adult patients with childhood trauma are encouraged to imagine their trauma from the point-of-view of an adult rescuing and protecting the vulnerable child. Imagery rehearsal therapy helps people with nightmares by documenting their dreams and creating new endings to them. They then write down their dreams, monitor them, and regularly act out the improved dream scenarios. "Cognitive therapy" of this kind should not be confused with the earlier established cognitive therapy of Aaron Beck. Ehlers and Clark inspired cognitive therapy is strongly recommended for treatment of PTSD by the American Psychological Association. Prolonged exposure therapy Prolonged exposure therapy (PE) was developed by Edna Foa and Micheal J Kozak from 1986. It has been extensively tested in clinical trials. While, as the name suggests, it includes exposure therapy, it also includes other psychotherapy elements. Foa was chair of the PTSD work group of the DSM-IV. Prolonged exposure therapy typically consists of 8 to 15 weekly, 90 minute sessions. Patients will first be exposed to a past traumatic memory (imaginal exposure), after which they immediately discuss the traumatic memory and then are exposed to, "safe, but trauma-related, situations that the client fears and avoids". Slowed breathing techniques and psychoeducation are also touched on in these sessions. PE is theoretically grounded in emotional processing theory, which proposes "a hypothetical sequence of fear-reducing changes evoked by emotional engagement with the memory of a significant event, particularly a trauma." While PE has received substantial empirical support for its efficacy (albeit with high dropout rates), emotional processing theory has received mixed support. PE is strongly recommended as a first-line treatment for PTSD by the American Psychological Association. Cognitive processing therapy Cognitive processing therapy (CPT) was developed by Patricia Resick from 1988. It is an evidence-based treatment aimed at individuals diagnosed with PTSD. This therapy focuses on processing and working through the trauma, designed using techniques from Cognitive Behavioral Therapy discussed previously. CPT is founded on the principle that generally, individuals can gradually recover from traumatic events over time, but in those diagnosed with PTSD, this recovery pathway is impaired. During therapy sessions, clients write and recite written passages either related to why the individual thinks they were exposed to the traumatic event, or narratives outlining the event in explicit detail. CPT is typically completed over 12 one-hour weekly sessions with a practitioner. The first phase of treatment is psychoeducation. During this part of therapy, individuals learn about the relationship between thoughts and emotions, and importantly, they look for "automatic thoughts" The patient discusses their distressing thoughts as the therapist reinforces positive cognitions and utilizes strategies such as a body scan. These sessions are usually once or twice a week for about 6 to 12 weeks. By the end of these sessions, individuals usually demonstrate reduced emotional distress related to the traumatic event. The methodology behind EMDR focuses on the Adaptive Information Processing model of PTSD Therapy with the incorporation of EMDR has been shown to aid patients in processing distressing memories and reducing their harmful effects. A proposed neurophysiological basis behind EMDR is that it mimics REM sleep, which plays a vital role in memory consolidation. Imaging studies suggest that "eye movements in both REM sleep and wakefulness activate similar cortical areas". The bilateral stimulation facilitated by EMDR "shifts the brain into a memory processing mode", reintegrating the traumatic events with more positively reinforced cognitions. The information can then be integrated completely to lessen the symptoms of triggers. The restoration of the pathway can help with recovery from traumatic events. Some social scientists argue that EMDR is a purple hat therapy. Narrative exposure therapy Narrative exposure therapy creates a written account of the traumatic experiences of a patient or group of patients, in a way that serves to recapture their self-respect and acknowledges their value. Under this name it is used mainly with refugees, in groups. It also forms an important part of cognitive processing therapy. Patients are asked to narrate their life-story while staying in the present moment. They receive an autobiography at the end from their therapist and this often serves as motivation to complete their narration. It emphasizes the psychodynamic perspective of shame and guilt in addition to the principles of cognitive-behavioral therapy. In 16 sessions, patients create a detailed account of the primary trauma experience, explore the connected emotional reactions, and how to move forward. The first few sessions deal with the traumatic experience as well as reliving the event in the present using objects or core memories. Through this process, the client discusses upsetting feelings and emotions as the therapist helps them to process the event. The individual also writes a letter to the person or group they feel holds responsibility for the trauma although it is not sent. The therapists then assist the individual in assessing the impacts of the trauma from beliefs to physical changes to help them learn and grow from the event instead of avoiding and fearing the impacts. Finally, the therapist helps to develop relapse prevention methods and looks forward to a better future. Dialectical behavioral therapy Dialectical behavioral therapy is a branch of cognitive behavioral therapy aimed at helping individuals to "accept the reality of their lives". Therapists use strategies such as behavioral therapy techniques and mindfulness to address thoughts and behaviors, and help individuals to regulate and change these. It is usually recommended and used in patients with borderline personality disorder and other personality disorders which are difficult to treat. The specific skills focused on are mindfulness, distress tolerance, interpersonal effectiveness, and emotional regulation. The main goal of DBT is to help clients manage their treatment and better understand their symptoms. The focus of DBT for PTSD is the future and adapting to the symptoms of the trauma. DBT has been studied as another potential treatment for PTSD. When used during partial hospitalization (PH) and intensive outpatient (IOP) programs, it's been reported to help reduce depression, anxiety, and hopelessness - at the same time improving mindfulness. Even in studies where PTSD was not the main focus, these programs have been connected to improvements in PTSD symptoms and mood. As of yet, DBT isn't recommended as a primary PTSD treatment, but using DBT in PH and IOP programs in combination or as a supplement with other therapies like PE, CPT, or EMDR has been explored. A major premise of EFT is that emotion is fundamental to the construction of the self and is a key determinant of self-organization. At the most basic level of functioning, emotions are an adaptive form of information-processing and action readiness that orient people to their environment and promote their well-being. EFT suggests that the developing cortex added the ability for complex learning to the emotional brain in-wired emotional responses. It was also shown that negative social support intensifies PTSD. Metacognitions control the negative thoughts and ruminations prevalent in many psychiatric diseases such as PTSD. Metacognitive therapy (MCT) was developed by Adrian Wells and is based on an information processing model by Wells and Gerald Matthews. This psychotherapy aims at changing metacognitive beliefs that focus on states of worry, rumination, and attention fixation. As per the metacognitive model, the symptoms are caused by worry, threat monitoring, and coping behaviors that are thought to be helpful but actually backfire. It has also shown clinically significant results for different causes of PTSD such as accident survivors, and assault and rape victims. The Australian Psychological Society considers metacognitive therapy (MCT) to be a Level II treatment method. The Australian Psychological Society considers mindfulness-based stress reduction to be a Level II treatment method. Researchers began experimenting with virtual reality therapy in PTSD exposure therapy in 1997 with the advent of the "Virtual Vietnam" scenario. Virtual Vietnam was used as a graduated exposure therapy treatment for Vietnam veterans meeting the qualification criteria for PTSD. A 50-year-old Caucasian male was the first veteran studied. The preliminary results concluded improvement post-treatment across all measures of PTSD and maintenance of the gains at the six-month follow up. Subsequent open clinical trial of Virtual Vietnam using 16 veterans, showed a reduction in PTSD symptoms. Exposure therapy remains a controversial form of therapy to treat PTSD. Those suffering with extreme re-experiencing and arousal symptoms may find exposure to be triggering. Confronting trauma too early after a traumatic event may be upsetting and only worsen symptoms for patients; severe negative reactions include self harm, panic disorder, dissociative disorder, and even suicidal thoughts. It is suggested exposure therapy, if used, should be resorted to only as second line of treatment—therapy ought to first focus on stabilizing and solving present symptoms before incorporating exposure. Occupational therapy Occupational therapy (OT) assists individuals in meaningful daily activities. OT helps individuals in response to an impairment such as an illness, disability, or in the case of PTSD, a traumatic event. Occupational therapists are equipped to address this meaningful area through sleep hygiene. Some examples of this technique are reducing screen time, developing nighttime routines, and creating a safe and quiet environment within the bedroom. Another meaningful area of occupational therapy is self-care. Occupational therapists provide education and adaptation/modification in self-care to maintain independence and prevent triggers that may cause flashbacks. Occupational therapists help clients with PTSD engage in meaningful life roles in daily lives, leisure, and work activities through healthy habit formation and stable daily routines while managing PTSD triggers. Occupational Therapy interventions are wide-ranging, from group therapy to therapy tailored to the specific cause of PTSD. Other more unique OT interventions include, high intensity sports, role playing scenarios, and sensory modulation therapy. One specific study with promising results, analyzed a sports-oriented OT intervention using surfing to help veterans with PTSD return to civilian life. Stress inoculation training Stress inoculation training was developed to reduce anxiety in doctors during times of intense stress by Donald Meichenbaum in 1985. It is a combination of techniques including relaxation, negative thought suppression, and real-life exposure to feared situations used in PTSD treatment. The first phase identifies the individual's specific reaction to stressors and how they manifest into symptoms. The second phase helps teach techniques to regulate these symptoms using relaxation methods. The third phase deals with specific coping strategies and positive cognitions to work through the stressors. Finally, the fourth phase exposes the client to imagined and real-life situations related to the traumatic event. This training helps to shape the response to future triggers to diminish impairment in daily life. == Biological interventions ==
Biological interventions
Biological therapy, which can also be referred to as biomedical therapy or biological interventions are any form of treatment for mental disorders that attempts to alter physiological functioning, including drug therapies, electroconvulsive therapy, and psychosurgery. Medication Pharmacotherapy is used to treat PTSD. A second-line treatment refers to a treatment that is used after the initial treatment has been shown to be unsuccessful or has stopped working when treating a specific condition. Antidepressants Antidepressants are widely used in the treatment of PTSD. The most popular types are SSRIs (selective serotonin reuptake inhibitors) and SNRIs (serotonin-norepinephrine reuptake inhibitors). According to the APA Practice Guidelines, "SSRIs have proven efficacy for PTSD symptoms and related functional problems". Despite this, it has been estimated that around 40-60% of patients with PTSD do not respond to SSRIs. The only two medications for PTSD that are approved by the FDA are sertraline (Zoloft) and paroxetine (Paxil), both antidepressants of the SSRI class. The APA clinical practice guideline also recommends the SSRI fluoxetine and the SNRI venlafaxine. Low levels of these three neurotransmitters have been linked with depression and anxiety. By blocking these enzymes, scientists believe that it helps relieve symptoms of depression. Benzodiazepines are a group of anti-anxiety medications that make people feel calm, relaxed, or sleepy. They are recommended for short-term treatment of severe anxiety, panic, or insomnia. Some authors believe that the use of benzodiazepines is contraindicated for acute stress, as this group of drugs can cause dissociation. Nevertheless, some people use benzodiazepines for short-term anxiety and insomnia. For those who already have PTSD, benzodiazepines may worsen and prolong the course of illness, by worsening psychotherapy outcomes, and causing or exacerbating aggression, depression (including suicidality), and substance use. The National Center for PTSD has claimed that if benzodiazepines are used by PTSD patients, patients may be unable to learn how to manage stress which makes it harder to recover. Effective treatments for PTSD, like talk therapy, help stop avoiding distressing situations and memories. Topiramate Topiramate is an anti-epileptic section of medications used to modulate glutamate transmission and could result in PTSD symptom reduction. However, the side effects of topiramate are greater than SSRI antidepressants so it is generally not recommended since it is not uncommon for patients to experience side effects such as cognitive dulling. Cognitive dulling refers to a form of mental fatigue that leads to difficulty concentrating, decreased productivity, and a decline in emotional and mental health, according to Jennifer Bahrman, assistant professor in the Louis A. Faillace, MD, Department of Psychiatry and Behavioral Sciences. Prazosin Prazosin, an alpha-adrenoceptor antagonist, is often prescribed, particularly for sleep-related symptoms. Early studies have shown evidence of efficacy, though a recent large trial did not show a statistically significant difference between prazosin and placebo. PTSD is strongly associated with nightmares, and it affects around 83% of people with the diagnosis. These nightmares are also connected to a higher risk of suicidal thoughts and behaviors, and while SSRIs and SNRIs are commonly used for symptoms during the day, they don't tend to relieve the persisting nightmares. Prazosin is explored as an option because, despite being originally used for blood pressure and heart conditions, it also crosses the blood-brain barrier and blocks α1 receptors in the brain. This calms the overactive nervous system, which helps improves REM sleep and reduces the intensity of the nightmares. There is some mixed evidence about the effectiveness of prazosin. Some studies report reduced nightmares and lower symptoms of PTSD, with 85% of psychiatrists describing it as either potentially or definitely effective. However, there were two recent clinical trials with no significant difference. Nightmares in PTSD can be resistant to treatment but are associated with serious issues, so a majority of psychiatrists will prescribe treatments like prazosin despite lacking enough promising evidence. Nepicastat Moreira-Rodrigues et al. demonstrated that mice lacking epinephrine exhibit reduced contextual memory after fear conditioning. In addition, in PTSD epinephrine enhances traumatic-contextual memory. Nepicastat is a drug that inhibits dopamine-β-hydroxylase (DBH), which is the enzyme that is responsible for the conversion of dopamine to norepinephrine. Studies have shown that nepicastat effectively reduces norepinephrine in both peripheral and central tissues in rats and dogs. Nepicastat also unregulated the transcription Npas4 and Bdnf genes in the hippocampus, potentially contributing to neuronal regulation and the attenuation of traumatic contextual memories. Although no DBH inhibitor has received marketing approval due to poor DBH selectivity, low potency and side effects, DBH gene silencing may be an alternative for patients with heightened sympathetic activity. Some studies, however have shown that nepicastat is well-tolerated in healthy adults and significant no differences in adverse events were observed. Given that nepicastat treatment has been proven to be effective in reducing signs in PTSD mice model with elevated catecholamine levels, Propranolol, a peripheral and central β-Adrenergic antagonist is effective on preventing the onset and progression of PTSD symptoms in humans however its beneficial effects are undermined by unwanted side effects like gastrointestinal disturbances, bradycardia, fatigue, sleep disorders and memory deficits. Sotalol is a peripherally acting β-Adrenergic receptor antagonist which has been proven to decrease traumatic contextual memories, anxiety-like behaviours and plasma catecholamines in animals Treatment of PTSD with sotalol may be a possibility if effective when using smaller doses. == Alternative and complementary therapies ==
Alternative and complementary therapies
Alternative medicine is any product or practice that is not considered part of standard medical care. Standard medical care, also known as standard of care, best practice, or standard therapy, is any treatment that is widely accepted as proper and correct by medical professionals. Complementary medicine is a treatment that is used alongside standard medical care, but is not part of that category itself. One example of this is acupuncture, hypnosis, or meditation. Alternative medicine, on the other hand, is used instead of standard medical care. These treatments may include specialised diets or the use of vitamins or herbs. Relaxation techniques Relaxation techniques may be the earliest behavioral treatment for PTSD, They can use relaxing movements such as successively tensing and relaxing muscles and works by reducing the fear associated with traumatic responses. Relaxation techniques include meditation, deep breathing, massages, and yoga. Yoga therapy treatment Yoga has shown promise of reducing symptoms of PTSD when is it used alongside other treatments. Yoga promotes a mind and body connection that can help empower people to embrace their own general wellness. Yoga also increases affect awareness and can help people learn to regulate their emotions, which can be instrumental in helping people overcome symptoms of PTSD. A randomised controlled trial including 209 participants, mainly veterans, showed a decrease in the severity of PTSD symptoms among the group that participated in a yoga program, as opposed to another group that participated in a wellness lifestyle program. After 16 weeks, the yoga group displayed a statistically significant decrease in PTSD symptoms compared to the other group. Some of these symptoms that were improved included sleep quality, emotional awareness, depression, anxiety, and others. The Clinician Administered PTSD Scale and the PTSD checklist were used to assess PTSD symptoms. These studies show that meditation reduces stress hormones by calming the sympathetic nervous system, which is responsible for the 'fight-or-flight' response to danger. Researchers found that practicing transcendental meditation can help reduce or even reverse symptoms of PTSD and associated depression. Specifically for this study, after 3 months of meditation, the group, on average, recovered from PTSD. Somatic therapy During somatic therapy, a person works with a therapist to modify the trauma-related stress response produced by their body. In addition to helping with emotional regulation, somatic therapy can also reduce trauma-related pain, disability, insomnia, and other manifestations of stress. Some common somatic therapy techniques are: • Body awareness: Learning to notice and identify feelings of tension and calmness in the body. • Grounding and centering: Using inherent self-awareness to connect with, manage, and mitigate feelings of distress as they arise. • Titration: The therapist guides the patient through recounting a traumatic memory while describing any tension or physical sensations that occur in the process. • Sequencing: The patient is asked to closely monitor the order in which sensations and tension leave the body, such as a tightening in the chest and a trembling as the tension dissipates. • Pendulation: The therapist guides the patient from a relaxed state to one that feels similar to their traumatic experience, allowing the patient to release pent-up pain and emotion. With these techniques, a person learns how to safely release built-up energy, pain, and emotions stemming from trauma. This allows a person to heal and move on from their PTSD triggers gradually. More research is needed before the American Psychological Association can list somatic therapy as a recommended treatment, but initial evidence has found it to be effective. Positive psychology Positive psychology coaching has been used as PTSD treatment, described as a strengths-focused method centered around reducing arousal states, meeting goals, and cultivating self-control. Past successful case studies of positive psychology interventions begin with journaling on strengths, completing a craft with fellow veterans, and group reflections answering positive psychology prompts. Reconsolidation of traumatic memories Reconsolidation of traumatic memories (RTM) is a treatment that was developed by clinical and research psychologist Frank Bourke around 2005. In RTM, a PTSD patient revisits, edits, and finally replaces their traumatic memory with an alternate version that is nonthreatening or even pleasant. Researcher Michael Roy presented further preliminary findings at two annual conferences of the International Society for Traumatic Stress Studies. PCT focuses on adapting to life stressors and developing responses to those stressors, and can be done in a group format or with an individual. Sessions will range from 60 to 90 minutes. Session numbers range from 12 to 32 for group sessions and 10-12 for individuals. This type of therapy can be a good option for people because it is often more accessible and cheaper. Studies have also shown various therapeutic benefits for group therapy. For example, group therapy allows people to work together and form meaningful relationships. It also helps people develop their communication skills. Another very important aspect is showing people who have PTSD that they are not alone. Oftentimes, group therapy can give people a community to support them when they feel detached from other people in their lives. As with any form of treatment, there are concerns for group therapy and it will not be the best option for every individual. One concern is that people will compare their trauma and experiences to others in a group setting, instead of learning and helping each other. The goal of animal-assisted intervention is to improve a patient's social, emotional, or cognitive functioning and literature reviews state that animals can be useful for educational and motivational effectiveness for participants. The most commonly used types of animal-assisted intervention are canine-assisted therapy and equine-assisted therapy. Canine therapy, because it is much more easily accessible, is the most commonly used form of animal assisted therapy. Service dogs have shown a lot of promise in mitigating PTSD symptoms, specifically among the veteran population. The mechanism for this may be that dogs help instil a sense of confidence and safety in their owner. They can also act as a companion for individuals who may otherwise experience detachment or feeling isolated and alone. Various studies, as well as lots of anecdotal evidence, have shown reduction in PTSD symptomatology with the use of service dogs and canine therapy. Physiologically, the presence of animals has been linked to the release of oxytocin and the reduction in anxious arousal symptoms, which is one of the most intrusive symptoms in many people with PTSD. There are both physical and psychological benefits to equine therapy and therapeutic horseback riding. The physical benefits may include improved posture and balance, decreased muscle tension, and reduction of pain. Psychological benefits include increased self efficacy, motivation, and courage, reduction in psychological stress, and enhanced psychological well-being. Equine therapy has been shown to be most effective when done over long periods of time. There are many different ways to participate in this type of therapy. People should pick whatever works best for them and is accessible, if this options speaks to them. Art therapy Art therapy may alleviate trauma-induced emotions, such as shame and anger. Through careful choice of art subject and form, such as self portraits, trauma survivors' are likely to build self confidence. Art therapy also has an established history of being used to treat veterans, with the American Art Therapy Association documenting its use as early as 1945. In addition, it has offered more reduction in trauma symptoms than just psychotherapy alone. Children's Accelerated Trauma Treatment Children's Accelerated Trauma Treatment (CATT) is a holistic trauma-focused therapy that fuses cognitive behavioural theory with creative arts methods, whilst taking a human rights and child-centred approach to treatment. CATT was initially created for children and adolescents at least 4 years old. However, CATT has since been used with individuals of all ages, including adults. Developed by Carlotta Raby in 1997 in London, CATT is based on empirical research and is UK NICE guidance and World Health Organisation (WHO) guidance compliant for PTSD and complex trauma treatments. A 2021 Gaza study found CATT to be an effective treatment for symptoms of trauma in children and young people, including PTSD. == Digital interventions ==
Digital interventions
Digital delivery is an expansion of telemedicine that focuses on symptom monitoring and clinical services. Modern technologies allow the usage of multiple engagements of interactions, such as smartphone usage for messaging, video calls, and completing self-report measures. The integration of digital delivery has various forms to provide multiple modalities, such as platforms with both synchronous and asynchronous interactions (e.g., instant messaging with a provider). The utilization of digital interventions is important because of barriers to seeking treatment, such as stigma, difficulties in scheduling, waitlist, and limited mental health resources. There is some concern about how these digital intervention will translate from research settings to real world settings. Virtual reality can help users feel more comfortable facing stressful situations in a virtual setting to learn new behaviors for real-life situations. A meta-analysis suggested that VRET is an effective treatment for PTSD and depression symptoms, with treatment benefits maintained for up to 6 months. However, these results were limited to male service members, which reduced the generalizability to women and other trauma populations. PTSD Coach was designed for service members and veterans and as a public health resource for any individuals impacted by trauma. Many studies support the feasibility and effectiveness of PTSD Coach as a mobile health intervention for self-management care of PTSD symptoms. One study found that most users accessed the app to manage symptoms through the use of a coping tool (e.g., cognitive restructuring). TAM is technology acceptance through an individual's perspective of ease of use, usefulness, and subjective norms. == Cannabinoids ==
Cannabinoids
Recent research has shown that cannabis is beneficial for PTSD Treatment according to the VFW (Veterans of Foreign Wars) in those who receive doses with higher levels in THC. According to Mallory Lofl, a volunteer assistant professor of psychiatry at the UC San Diego School of Medicine, one of the biggest takeaways from this study is that veterans with PTSD can use cannabis at self-managed doses, at least in the short term, and not experience a plethora of side effects or a worsening of symptoms. Currently, 37 states, four territories, and the District of Columbia allow the use of cannabis for medical purposes. Two studies that have been published recently showed two different mechanisms that allow cannabinoids to help with PTSD. One showcased cannabis's effect in the amygdala — a part of the brain associated with fear responses to threats — by reducing activity in that region. == Psychedelic assisted psychotherapy ==
Psychedelic assisted psychotherapy
Psychedelic therapy is the use of psychedelic substances such as MDMA, psilocybin, LSD, and ayahuasca to treat mental illnesses. Most of these substances are controlled substances in most countries and are not legally prescribed. They are mostly used in clinical trials. The way of administering psychedelic drugs is different from most other medical drugs. Psychedelic drugs are usually given in a single sessions or a few sessions after which the patient wears eyeshades and listens to music so that they can focus on the psychedelic experience. The therapeutic team is available in case of any distress or anxiety. Psychotherapy itself often does not cause complete recovery in PTSD patients. The investigation of psychedelic drugs as an alternative to antidepressants and psychotherapy is becoming popular and there are many clinical trials being run on this. The advantage of using psychedelic drugs is that many of these drugs are not physically addictive, unlike drugs like nicotine. The disadvantages of using psychedelics include the risk of a "bad trip" causing the patient to feel unsafe and causing long-term negative impact on their mental state. Some patients have also reported flashbacks upon taking psychedelics thus decreasing their overall well-being by bringing back the memories causing PTSD. MDMA In 2018, the US Food and Drug and Drug Administration granted "Breakthrough Therapy" designation for MDMA-assisted psychotherapy trials. There is weak evidence MDMA might improve PTSD symptoms, with possible adverse effects including nausea and jaw clenching. In August 2024 the FDA rejected the approval of MDMA due to methodological limitations and uncertainty regarding adverse effects. MDMA has potential to be a promising treatment for PTSD because it decreases fear, increases wellbeing, increases sociability, increases trust, and creates and alert state of consciousness. This happens through its effects on neurotransmitters and hormones - this includes the release of serotonin, norepinephrine, oxytocin, cortisol, and dopamine and the reduction of blood flow to the amygdala - which help remove symptoms of PTSD like fear, anxiety, and trauma. While doing all this, MDMA promotes brain plasticity, which improves mood and encourages positive emotions like joy, friendliness, and empathy. This helps patients them more easily process their memories and changes their views on life and purpose. Only 2-3 sessions of MDMA-assisted psychotherapy have shown positive results for reducing symptoms of PTSD. Psilocybin Some studies have shown that mice overcome fear after being given psilocybin. This is because psilocybin stimulates the growth of neurons in the hippocampus which is the area of the brain responsible for memory and emotion. Ketamine Ketamine has been shown to rapidly decrease PTSD symptoms by altering memory processes such as increases in fear extinction. Ketamine therapy in combination with exposure therapy has promising effects for the treatment of PTSD. There are clinical trials that have tested and support the potential of ketamine treatment for PTSD management, although the findings are a bit mixed. Some studies reported significant short-term improvements in PTSD symptoms after going through multiple ketamine infusions, while others show more antidepressant effects without any clear signs of PTSD symptom reduction. The differences in dosage and treatment duration play a part in how different each outcome was, and there are limitations due to low numbers of participants and not enough clinical trials. More research needs to be done in order to better understand which conditions allow ketamine to have the most effective treatment for PTSD. == Neurological interventions ==
Neurological interventions
Acupuncture Acupuncture is a practice using small needles to penetrate the skin in specific areas of the body to stimulate the nervous system. This technique has evolved from traditional Chinese medicine that utilizes over 2000 acupuncture points to change energy flow in the body. Individuals with PTSD often have several comorbidities and acupuncture has been shown to assist in diminishing these symptoms. The evidence for this practice are based in the stimulation of the "autonomic nervous system, and the prefrontal as well as limbic brain structures, making it able to relieve the symptoms of PTSD". Acupuncture is a safe practice that shows promise in the field of many health conditions and research supports the practice in reducing PTSD symptoms. Stellate ganglion block Stellate ganglion block (SGB), also known as cervical sympathetic blockade (CSB), involves an injection of local anesthetic to inhibit peripheral sympathetic nerves in the neck that mediate the fight-or-flight response. While some preliminary research has suggested that SGB might benefit some individuals with refractory PTSD, results are mixed with regard to effectiveness. SGB is an unproven, experimental treatment. Repetitive transcranial magnetic stimulation therapy Repetitive transcranial magnetic stimulation (rTMS) is a non-invasive neuromodulation technique that has been investigated as a possible PTSD treatment, but preliminary research has not demonstrated treatment efficacy. == Multicultural perspectives ==
Multicultural perspectives
Trauma is ingrained in culture, and different cultures receive and treat trauma in different ways. Some cultures treat trauma with ancient practices such as praying or ritual. It is defined as ongoing trauma experienced across generations by a group that shares an identity, affiliation, or circumstance. Native Americans, African Americans, Holocaust survivors, and Irish people are communities who may experience historical trauma. In the case of Native Americans, many therapists use "a return to indigenous traditional practices" as a form of treatment for HT. This is very different from Cognitive Behavioral Therapy or SSRIs that may be prescribed for someone with PTSD. The goal of this kind of treatment is not "adaptation" or cognitive restructuring of the individual to the prevailing cultural norm, "but rather spiritual transformations and accompanying shifts in collective identity, purpose, and meaning making." A combination of Western psychotherapy and Japanese culture is helpful when using psychotherapy as an effective treatment in Japan. "After the Kobe-Awaji earthquake in 1995...Japanese psychologists became acutely aware of the need to receive specialized training in the treatment of post-traumatic stress disorder (PTSD) as well as crisis intervention." Psychotherapy is a recent practice used in Japan in which some practices of western psychotherapy are "modified to suit the Japanese client population" and forms to create a sense of cultural integration. The  two main methods of treatment practices Japanese psychotherapists work with are nonverbal tasks and parallel therapy. ==Recommendations==
Recommendations
A number of major health bodies have developed lists of treatment recommendations. These include: • American Psychological AssociationUnited States Department of Veterans Affairs • The UK's National Institute for Health and Care ExcellenceAustralian Psychological Society == See also ==
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