Keightley played nine
Tests and 85
One Day Internationals for the
Australia women's national cricket team between 1995 and 2005 She holds the record for the highest ever maiden ton in Women's ODI history (156*) She played 91 matches in the domestic national cricket league, scoring 3081 runs at 37.12 with 3 centuries, 21 fifties and a highest score of 144*. She also took 10 wickets at 27.6. On 30 October 2019, Keightley was appointed head coach of the English women's team, the first woman to hold the post full-time. She had previously coached
New South Wales, Australia women,
Western Australia and
Perth Scorchers, as well as leading the England Women's Academy. Keightley left the position at the end of England's 2022 home summer. In December 2024, she was named as the new coach of the
Northern Superchargers women's team. In September 2025, she was named the new head coach of the
Mumbai Indians after
Charlotte Edwards resigned to become coach of the
England team. == One Day International centuries ==