Shaw presented her last programme for BBC Radio Newcastle on 7 May 2021. She died at Newcastle's
Royal Victoria Infirmary on 21 May, aged 44. Her family told media reporters that, days after having received a first dose of the
Oxford–AstraZeneca COVID-19 vaccine, Shaw, who was not known to have any underlying health problems, became seriously ill and was treated for
blood clots and cerebral bleeding. On 27 May, it was reported that her death would be investigated in a coroner's inquest.
Sky News reported that senior Newcastle coroner Karen Dilks had issued an interim fact-of-death certificate citing a "complication of AstraZeneca COVID-19 virus vaccination" as a consideration.
BBC News reported in August 2021 that the coroner had concluded in her final judgment that it was "clearly established" Shaw's death was caused by an extremely rare "vaccine-induced thrombotic thrombocytopenia", a condition which leads to a brain haemorrhage. The
National Institute for Health and Care Excellence (NICE) published medical recommendations for the condition in July 2021 matching the treatment Shaw was given. Shaw's funeral was held on 10 June at
Durham Cathedral. Following the service her family announced plans to establish a charity to provide holidays and activities for bereaved children who have lost a parent. The charity, Lisa Shaw's Little'uns, is named after a feature on her BBC radio show. ==Personal life==