In the
2021 Dutch general election, she was elected into the House of Representatives. She was the 22nd candidate on D66's
party list and received 10,969
preference votes. Van Ginneken had decided to run for office because of comments by
Thierry Baudet, the leader of the conservative and populist party
Forum for Democracy, during the campaign for the
2019 provincial elections. Van Ginneken was sworn into the House on 31 March 2021 as the first transgender member in its history. She simultaneously left Transvisie and the Netherlands Institute for Human Rights. Van Ginneken was D66's spokesperson for
ICT, digital government, intelligence agencies, privacy,
family law, identity, roads, mobility, railways, and public transport. She is a member of the Committees for Agriculture, Nature and Food Quality; for Digital Affairs; for Economic Affairs and Climate Policy; for Foreign Trade and Development Cooperation; for Infrastructure and Water Management; for the Interior; and for Justice and Security as well as of the
Benelux Parliament and the Building Advice Committee, which advises on the renovation of the
Binnenhof. In an interview, she argued for investing more in the European technology industry, calling the continent's technological dependency on the United States and China a threat to privacy protection. The
Council of State advised negatively on the amendment for legal reasons, and Van Ginneken subsequently drafted a bill instead. She also defended a revised Transgender Act that was proposed by the
fourth Rutte cabinet and that would remove the requirement for a statement by a psychologist or psychiatrist to change one's legal gender. Van Ginneken said that the barrier leaves the impression that transgender people are not able to make this decision by themselves and that its removal would aid in self-development. She discarded worries about men changing their gender to enter women's changing rooms, noting that passports are not checked at the door. She received the 2021 Pride Award in the category Well-known
LGBTI+ Hero. The chair of the jury,
Cornald Maas, called the fact that she is the House's first female transgender member "important and historic". Van Ginneken announced in November 2022 that she would leave social media platform
Twitter, as healthy debate was being undermined by hateful comments according to her. == Personal life ==