Taiyo Sphinx The are a team based in the Kanagawa prefecture. They are renowned for their "Pyramid Line" composed of strong and heavy offensive and defensive linemen. Its members include
Banba Mamoru, the captain, an eccentric quarterback who has his own harem and is considered a below average player, the second-largest player of the Pyramid Line who is easily irritated and tricked, a tall first-year cornerback whose speciality is the
bump technique.
Mamoru Banba : is the Taiyo Sphinx's captain. Considered one of the best linemen in Japan, he is a third-year student who holds the school record for
squats. He is distinguished by his massive physique, complete baldness, and, during the Kantō Tournament, multiple scars from training. Later, he serves as a personal coach for
Shozo Togano during the Devil Bats' preparation for the Christmas Bowl.
NASA Aliens The are a team based in
Houston, Texas. The team was known as the before they changed their name after their loss to the Devil Bats in a match they have bet with Hiruma that if the NASA Aliens could not win with a lead of ten points or more, they would not return to the United States. Then its coach,
Leonardo Apollo, changed the team name to return to their home country. Its members include
Panther, the running back, the quarterback whose specialty is a long pass known as the "Shuttle Pass",, the
Japanophile wide receiver, and two brothers, and the former is tall and strong and the latter smaller, but faster. Inagaki visited a
space center to collect reference materials to use as a basis for creating the team.
Panther : , most known as , is the only black member of the NASA Aliens. He is also known as because he has innate and extraordinary running talents. However, by the start of the series, he is just used as a ball boy by the team coach,
Leonard Apollo. Panther struggles because he has the dream of becoming a professional NFL player to sustain his grandmother, and also because he admires Apollo. Apollo allows him to play for the first time in the match against the Devil Bats. Later, he is recruited by the
Team USA.
Leonard Apollo : is the coach of the NASA Aliens team. He is a former professional, NFL player, known for his dedication to training. When he is removed from the team in favor of Morgan, a black man with innate talents, he becomes a
racist, not only against African-American but to Japanese as well. After this event, he decided he would form the best team possible with only white players, and due to this attitude, he initially forbids Panther for playing. However, he changes his mind after all members of the Aliens do a
dogeza to ask him to let Panther play.
Kyoshin Poseidon are a team known for its members' height. Its members include
Shun Kakei, the main linebacker,
Kengo Mizumachi, the main lineman, the
de jure captain of the team, and the two tallest high school football players in Japan, and who greatly admire Kakei.
Shun Kakei : is a linebacker and the
de facto captain of the team due to Osamu's shyness. During middle school, he was considered an exceptional player because he was taller than the other Japanese students. Because of this, he moved to the United States to play football there, but realized he was not as good as he thought he was. Kakei almost abandoned football after his team lost to Notre Dame but after meeting Notre Dame's Eyeshield 21, who was also Japanese, he decided to train more to face him again. Kakei achieved his goal, but Eyeshield 21 disappeared, which caused him to return to Japan to find him. There, Kakei enrolled at Kyoshin. Before Kyoshin and Deimon play against each other in the fall tournament, Kakei dismisses Sena as a fraud due to him not resembling the Eyeshield 21 he faced in America but changes his mind after Sena and Deimon win against Kyoshin. Both Kakei and Sena discover from
Hayto Akaba that Eyeshield 21 is in fact a title passed onto the best runner at Notre Dame and that the "real" Eyeshield 21 Kakei played against was
Takeru Yamato. Kakei helps to train
Jumonji Kazuki before the match between Devil Bats and Alexanders.
Kengo Mizumachi : is the main lineman of the Kyoshin Poseidon. During middle school, he was known as a genius with a natural gift for sports, being requested by several teams. He joins and becomes a champion at the swimming club, but he quits due to his teammates lacking the drive to win; he is eventually recruited by Kakei to the American football team. Later, he serves as a personal coach for
Koji Kuroki during the Devil Bats' preparation for the Christmas Bowl. At the end of the series, he is shown to be attending Enma University.
Bando Spiders The are a team of
specialists that focus on scoring through field goals. One year prior the series' events, most of its members were recruited away by the
Teikoku Alexanders after the team achieved the second place in the Tokyo Tournament. The team's main player is
Kotaro Sasaki, the one responsible for scoring, who has the help of
Hayato Akaba, the one in charge for blocking the adversaries. The team is managed by a childhood friend of Kotaro.
Hayato Akaba : is the tight end and the captain of the Spiders. He is obsessed with music, often plays his electric guitar, and uses musical metaphors to state his opinions. A year before the start of the series, Akaba was named MVP in the fall Tokyo Tournament, which attracted the attention of Teikoku Alexanders. He joined the Alexanders and was given the title of Eyeshield 21 by who had retired the name, but soon he decided to return to Bando. Because of this last minute change, Akaba is banned from playing for six months due to the school's policy, and during this time he is devoted to studying new tactics to teach his teammates. He introduces himself for the match against the Devil Bats as "the real Eyeshield 21". After his team is defeated, he officially hands Sena the Eyeshield 21 title and serves as a personal coach for
Natsuhiko Taki during the Devil Bats' preparation for the Christmas Bowl. Akaba is also recruited for Team Japan during the World Tournament. At the end of the series, he is shown to be attending Saikyodai University.
Kotaro Sasaki : is the kicker of the Bando Spiders. A skilled kicker, he has an average of 100% success of converting
extra points. However, he aims to hold the title of the best kicker in Japan and then he wants to face
Musashi as he heard the urban legend of Musashi's sixty-yard field goal. Due to his abilities, Sasaki is invited to join the Teikoku Alexanders, but rejected the offer to stay with
Hayato Akaba. At the end of the series, he is shown to be attending Enma University.
Hakushu Dinosaurs The are a team from the SIC region (
Saitama,
Ibaraki, and
Chiba), participating for the first time in the Kantō Tournament. Its members include
Reiji Maruko, the quarterback and captain,
Rikiya Gao, the main lineman, the wide receiver who is considered the team's left arm, the team's former "ace", the kicker who proclaims himself the third best, and the club's manager who although admires Marco's ambition does not appreciate his methods to win.
Reiji Maruko :
Other Rui Habashira : is a linebacker and the captain of the a team whose members are mainly delinquents led by him. Habashira is the son of a senator; as such, he can allow players, who should be under police custody, to play games. He acts like a thug in order to gain respect from his teammates, and he forces them to practice through threats and violence. However, he is the only one in the team who really cares about American football. He enters the international tournament as the "Mummy Man" in order to play while also making sure his teammates are not thinking he is wasting time.
Onihei Yamamoto : is a lineman the captain of the He is greatly admired and respected by other linemen, especially
Ryokan Kurita. He is very powerful despite his small body, and is known for his great technique and experience. After the elimination of his team from the Autumn Tournament by
Kyoshin Poseidon, he befriends
Torakichi, who quite accurately believes, after observing some of Onihei's predictions, that anything that Onihei predicts is wrong.
Devil Bat is the main mascot of the
Deimon Devil Bats. It is a
bat-like creature with red coloration, horns and tail similar to the common stereotype of the
devil. Devil Bat usually appears to explain the rules of American football to the audience.
Cerberus is Hiruma's
dog and one of the Devil Bats' mascots. In the manga, Hiruma finds the dog on a rainy day while placing flyers and is attracted to take it with him because of its fierce look. Differently, in the anime, Cerberus appears in the training field, Hiruma challenges it, and after succeeding in putting the collar on it, the canine starts to obey Hiruma's commands. Hiruma often uses Cerberus to frighten his adversaries as well as his own teammates. Cerberus is also used to help to keep Sena's secret identity; for example, with some pet food in a bowl, a Sena doll, and a camera, Hiruma can make it appear that Sena is recording games, while in fact, he is playing as Eyeshield.
Torakichi : is a grade-school fan of
Sakuraba, who wishes to become a player after witnessing Sakaruba catching a very high pass. Even when Sakuraba says he caught that pass by accident and when Torakichi learns Sakuraba is really a sub-par player, Torakichi remains a loyal fan and encourages him to become stronger. Torakichi plays
flag football until he is hospitalized with a broken leg, which leaves him unable to play football for up to two years. He almost gives up on his dream, but he is inspired by Sakaruba to continue with his rehabilitation..
Kumabukuro, Sanada and Riko : and are, respectively, the official
commentator and the
announcer of American football games. Kumabukuro is a retired American football player, who becomes a reporter for the
American Football Monthly magazine. Kumabukuro's daughter, , is a 16-year-old girl studying to become a sports reporter. Riko replaces her father as Sanada's commentating partner from the Kantō Tournament onward.
Masaru Honjo : is a former baseball player of the Shuei Bears team. He played as an
outfielder and was known for his extraordinary catches, which leads
Monta to become his fan. After retiring from baseball, he became a chairman of Kansai's High School Football Association after being invited by a friend, the head commissioner of Kanto's High School Football Association, who believes Honjo's presence would help to attract fans.
Nakabo Akira , most known as , is a middle school student, who admires Sena and wishes to become an American football player after seeing him. He attempts to try out for the Japanese team for the international tournament by copying Sena's moves. Though he is initially laughed at, he shows that he can use the "Delta Dynamite", a blocking technique that involves ramming the enemy with the head, shoulder, and fist simultaneously in a delta shape, which makes the block three times more powerful. He becomes a prominent lineman on the team, though if his timing is messed up, he is very weak on the field.
Team USA Team USA is coached by former NFL star who will pay 300 million yen to the
MVP from the world tournament's winning team and sign him to his NFL team, Five first-string players for Team USA share the title of "Pentagram", named for the stars on the
American flag. These five players are regarded as the top candidates for the MVP award. The team is formed by the lineman and the leader of Team USA and the son of the president;
Panther of the Shuttles is the running back of the team; the arrogant
quarterback, who is known as the the
cornerback and an action movie star in Hollywood, and the
Native American linebacker, who is known as the as he is the tallest player within the tournament.
Eyeshield 21 is the title of the best runner of a generation. At the start of the series, Hiruma assigns this name to Sena to frighten his adversaries by claiming he is the running back who came from Notre Dame to Japan. "Eyeshield 21" is in fact not a person but a tradition of the (fictional) high school affiliated to the
University of Notre Dame to distinguish the best player of the team by awarding them with a distinctive blue
eyeshield and the number "21" for their
jersey.
Shun Kakei, however, reveals that he had met the "real" Eyeshield 21 when he was in the United States, and he returned to Japan to search him and denounces Sena as a fraud. During the match between
Deimon Devil Bats and
Bando Spiders,
Akaba Hayato is revealed to be the "official" carrier of the Eyeshield 21 title; after being defeated by Sena and the Devil Bats, Akaba passes the title onto him. However, the "real" Eyeshield 21 that Akaba previously inherited the title from is revealed to be
Takeru Yamato, the true identity of the person Kakei met in the United States. When he meets Sena, Yamato declares that whoever wins the Christmas Bowl between the Deimon Devil Bats and the Teikoku Alexanders will be the one who deserves the title. ==Reception==