2009 The first batch of ministers in the NDC government were sworn in on 13 January 2009.
Betty Mould-Iddrisu who was initially out of the country was later sworn in as Ghana's first female Attorney General and Minister for Justice. Muntaka Mohammed Mubarak, the Minister for Sports, resigned on 25 June 2009 following findings of financial impropriety against him by a committee set up by government.
2010 On 25 January 2010, President Mills conducted his first cabinet reshuffle. There were changes of ministers in 7 ministries and one change of regional minister. In all, four new ministers came into government including Alban Bagbin, the Majority Leader in parliament and his deputy, John Tia. Also in were Enoch T. Mensah, a former minister in the Rawlings NDC government and Martin Amidu, the new Interior minister. On 11 May 2010, Mahmud Khalid, the Upper West Regional Minister was dismissed by President Mills. Khalid suggested members of his party lobbied for his dismissal. and approved by parliament on 23 July 2010.
2011 The second cabinet reshuffle by President Mills was in January 2011. 9 ministries were affected in all. One Regional minister was also changed. Notable changes including replacing Betty Mould-Iddrisu with Martin Amidu as Attorney-General. Zita Okaikoi and Alex Tettey-Enyo were dropped from government. A few days later, Betty Mould-Iddrissu, Minister for Education who was the Attorney-General before Amidu tended her resignation as Minister for Education. This was accepted by President Mills who appointed Enoch Mensah to replace her as Minister for Education temporarily. A cabinet reshuffle was announced a few days later via a press release from the Office of the President. There were new ministers nominated for approval by parliament. These include William Kwasi Aboah for Interior, Lee Ocran for Education, Fritz Baffour MP for Ablekuma South for Information, Moses Asaga for Employment and Social Welfare, Dominic Azimbe Azumah, MP for Garu - Timpane – Minister of State and Amin Amidu Sulemani, Upper West Regional Minister designate. On 26 March 2012, President Mills appointed two new regional ministers. The former ambassador to the
Czech Republic, Victor Emmanuel Smith became the new Eastern Region Minister and the MP for
Buem, Henry Kamel Ford became the new Volta Region Minister. ==Death of President Mills==