Little Mahantango Creek is a tributary of Mahantango Creek in Schuylkill County and Northumberland County, in Pennsylvania, in the United States. It is approximately 9.6 miles (15.4 km) long and flows through Eldred Township and Upper Mahantongo Township in Schuylkill County and Upper Mahanoy Township in Northumberland County. The watershed of the creek has an area of 15.1 square miles (39 km2). The creek has many unnamed tributaries and sub-tributaries; all of them, as well as the main stem, are impaired. The cause of impairment in Little Mahantango Creek is sedimentation/siltation and the probable source of impairment is agriculture.