While the show initially focused on the character of Macarena Ferreiro, portrayed by Maggie Civantos, it became an
ensemble show.
Cruz del Sur female inmates •
Maggie Civantos as Macarena Ferreiro: A young woman sentenced to prison for seven years due to embezzlement. (season 1–2,
Oasis; Recurring: season 3–4). •
Najwa Nimri as Zulema Zahir: Known as the queen of prison due to her criminal records and illegal activities even while incarcerated. (season 1–4, Oasis). •
Berta Vázquez as Estefania "Rizos" Kabila: A young prisoner in prison for four years due for auto theft. (season 1–4). •
Alba Flores as Saray Vargas de Jesús: A young woman sentenced for assault. (season 1–4, Guest: Oasis). •
Inma Cuevas as Ana Belén "Anabel" Vila Roig Garcés: A woman sentenced to 9 years for prostitution and drugs. (season 1–3). •
María Isabel Díaz Lago as Soledad Núñez Hurtado: A prisoner who burned her husband and mistress to death. (seasons 1–4). • Laura Baena as Antonia Trujillo Díez: The prison cook, must serve 5 years. •
Belén Cuesta as Yolanda Montero
Cruz del Sur employees •
Roberto Enríquez as Fabio Martínez León: A hot-tempered prison guard and former police officer. (season 1–2, Guest: 3). •
Ramiro Blas as Carlos Sandoval Castro: The prison doctor of Cruz del Sur and director of Cruz del Norte. (season 1–2,4, Guest: 3,
Oasis). •
Cristina Plazas as Miranda Aguirre Senén: The director of Cruz Del Sur. (season 1–2). • Alberto Velasco as Antonio Palacios Lloret: A friendly prison guard.(season 1–2,4). • Harlys Becerra as Ismael Valbuena Ugarte: An antagonistic chief prison guard. (season 1–2). •
Ana Labordeta as Paloma Garrido "Governor": The head prison guard. (Recurring season 1).
Macarena's family •
Carlos Hipólito as Leopoldo Ferreiro Lobo: Macarena's father and former police guard. (season 1–2). • as Encarna Molina: Macarena's mother. (season 1–2). • Daniel Ortiz as Román Ferreiro Molina: Macarena's older brother. (season 1–2, Guest: Oasis).
Cruz del Norte inmates •
Ruth Díaz as Mercedes Carrillo –A mother and a politician in the local district that was sentenced to prison due to corruption. (season 3; guest: 4). • as Akame: Leader of the Chinese gang in Cruz del Norte and antagonistic towards the newly transferred inmates from Cruz del Sur. (season 3). •
Ana Marzoa as Prudencia Mosqueira: Soledad's friend in prison. (season 3). •
Itziar Castro as Goya Fernández: One of the self-proclaimed leaders of Cruz del Norte and a drug dealer. (season 3–4, Oasis). •
Abril Zamora as Luna Garrido –A transgender inmate who befriended the Cruz del Sur inmates, also a drug addict. (season 3–4).
Cruz del Norte employees • Javier Lara as Álex Moncada: Director of Cruz del Norte. (season 3). •
Luis Callejo as Andrés Frutos: A prison guard who secretly trades with the Chinese inmates. (season 3). •
Adriana Paz as Altagracia Guerrero: An ex-prisoner and an antagonistic prison guard, Zulema's accomplice. (season 3–4). •
Cristina Marcos as Magdalena Cruz: Owner of Cruz del Sur, del Norte, del Oeste, and the newly planned del Este. (season 4). •
Benjamín Vicuña as Antonio Hierro: A strict prison guard assigned to monitor Zulema. (season 4). • Zaira Pérez as Nuria Millán: Prison guard in Cruz del Norte. (Recurring season 3–4).
Police •
Jesús Castejón as Inspector Damián Castillo: The head detective of the police force. (season 1–4, Guest: Oasis). •
Hugo Guzmán as Camilo Jalapeño: Inspector Castillo's partner. (Recurring season 2). •
Verónika Moral as Helena Martín: An undercover cop in prison.(season 2). •
Jose Javier Domínguez as Inspector Pipiolo: Inspector Castillo's partner. (Recurring season 2). • Irene Anula as Inspector Nerea Rojas: Inspector Castillo's partner, Rizos' love interest. (Recurring season 3).
Cast overview } : = Lead character : = Macarena Ferreio's relatives : = Inmates : = Prison staff : = Police inspectors : = Oasis Characters == Broadcast ==