Overview Main •
Rob Lowe as Owen Strand, a firefighter captain from New York City and TK's father. He was diagnosed with lung cancer as a result of being a
first responder to the
September 11 attacks, in which he also lost his entire firehouse. Having rebuilt his team in New York City, he was asked to do the same for the 126 in Austin. •
Liv Tyler as Michelle Blake (season 1), the
paramedic Emergency Medical Services (EMS) captain. She is trying to locate her sister Iris, who has been missing for three years.), a 9-1-1 operator and Judd's wife
Recurring •
Kyle Secor as Deputy Chief Alden Radford (season 1; guest season 2), a fire chief who convinces Owen to come to Austin to rebuild Station 126 • Mark Elias as Timothy M. Rosewater (seasons 1–2), a paramedic who is also a member of Rescue 126 EMS crew •
Jon Foster as Dustin Shepard (season 1), an ex-boyfriend of Michelle Blake's missing sister •
Brett Rice as Wayne Gettinger (season 1), an elderly man who is receiving chemotherapy treatments at the same time as Owen •
Mary Kay Place as Theresa Blake (season 1), Michelle's mother •
Natalie Zea as Zoe (season 1), a psychology professor at the
University of Texas at Austin. She meets Owen at a beauty supply store and later begins dating him. •
Billy Burke as Captain/later Deputy Chief William "Billy" Tyson (seasons 1 and 3; guest season 2), a former firefighter for the 126 who also has cancer •
Tamala Jones as Det. Sarina Washington (season 1; guest seasons 3–4), a detective with the Austin Police Department •
Lyndsy Fonseca as Iris Blake (seasons 1 and 4), Michelle's missing sister •
Lisa Edelstein as Gwyneth "Gwyn" Morgan (seasons 2–3; guest season 4), Owen's ex-wife and TK's mother, who arrives in Austin after her son's hospitalization •
Derek Webster as Charles Vega (season 2; guest season 5), Tommy's husband •
Robyn Lively as Marlene Harris (seasons 3 and 5; guest season 4), the mother of Judd's son, Wyatt •
Nathan Owens as Julius Vega (season 3), Charles' brother and Tommy's brother-in-law •
Neal McDonough as Sgt. Ty O'Brien (guest season 3; season 4), the Austin PD Sergeant First Grade who is known for both his by the book approach and his dislike of firefighters •
Amanda Schull as Special Agent Rose Casey (season 4), an FBI agent investigating members of an extremist group, with Owen's help •
D. B. Woodside as Trevor Parks (seasons 4–5), the new pastor at Tommy's church who becomes her love interest • Bella Blanding as Melody Parks (season 4-5), the daughter of Trevor Parks •
Ashley Rae Spillers as Lila Gerald (season 4), a woman Marjan saves who later sues her • Jamison Webb as Mitch Gerald (season 4), a man Marjan saves who later sues her •
Michaela McManus as Kendra Harrington (season 4), a charitable billionaire heiress who is Owen's love interest •
Amanda Payton as Jasmine Asha Fulton (season 4), AFD Department Advocate at the 126 •
Chad Lowe as Robert Strand (guest season 3; season 4), Owen's brother who has Huntington's disease • Andy Favreau as Pearce Risher (guest seasons 2–3; season 4), an egotistical paramedic who works briefly at the 126 then is employed by a private ambulance service •
Alan Autry as Chief Bridges (guest season 4; season 5), the former boss of Gabriel Reyes who also becomes Carlos's boss when the latter joins the Texas Rangers •
Parker Young as Sam Campbell (season 5), an Army veteran and Gabriel's former partner with the Rangers. He is initially skeptical of Carlos's abilities as a Ranger, but later develops respect for him.
Guest •
Alex Carter as Captain (season 1), the former captain of the 126 who is killed in the explosion •
Jesse Luken as Jake Harkes (season 1), one of the former members of the 126 who is killed in the explosion • Matt McTighe as Chuck Parkland (season 1), one of the former members of the 126 who is killed in the explosion • Graham Shiels as Cory Garrity (season 1), one of the former members of the 126 who is killed in the explosion •
Angel Parker as Josie (season 1), a woman who Paul meets on a call •
Barry Corbin as Stuart Ryder (seasons 1–3), Judd Ryder's father •
Sharif Atkins as Victor (season 2), a real estate agent that fell into a volcanic sinkhole while playing mini golf with his family •
Mena Massoud as Salim (season 2), Marjan's childhood friend to whom she has been arranged to be married since they were twelve •
William Allen Young as Benjamin Williams (season 2 and 4), Grace's father •
Barbara Eve Harris as Denice Williams (season 2 and 4), Grace's mother •
Bart Johnson as Stanley (season 3), Marlene's fiancé and Wyatt's future stepfather •
Adam Baldwin as Det. Brian McGregor (seasons 4 and 5), Austin PD detective •
Peyton List as Ashlyn Campbell (season 5), Sam Campbell's wife
Crossover cast Regular cast members of the original
9-1-1: •
Aisha Hinds as Henrietta "Hen" Wilson (special guest, season 2), L.A. firefighter and paramedic •
Ryan Guzman as Edmundo "Eddie" Díaz (special guest, season 2), L.A. firefighter •
Oliver Stark as Evan "Buck" Buckley (special guest, season 2), L.A. firefighter •
Angela Bassett as Athena Grant-Nash (special guest, season 3),
LAPD patrol sergeant ==Episodes==