Main •
George Lopez as Himself, Mayan's father • Mayan Lopez as Herself, George's daughter •
Matt Shively as Quinten Mark Van Bryan, Mayan's fiance • Brice Gonzalez as Chance Lopez-Van Bryan, Mayan & Quinten's son and George's grandson •
Selenis Leyva as Rosie Flores Lopez, George's ex-wife and Mayan's mother •
Al Madrigal as Oscar Rivera, an employee and friend of George's who is frequently
stoned • Noel the Rescue Dog as Churro, the
chihuahua family Dog
Recurring •
Laci Mosley as Brookie, Mayan's co-worker and friend •
Aparna Nancherla as Dr. Pocha, a veterinarian and Mayan's boss •
Caroline Rhea as Jana, a rich pushy lady at Mayan's vet • Moises Chavez as Raul, one of George's employees and friends •
Liz Torres as Daisy, Rosie's sister •
Rita Moreno as Dolores Lopez, George's grandmother •
Cheech Marin as Carlos, Rosie's
Curandero •
Stephen Tobolowsky as Sam Van Bryan, Quinten's father • Momo Rodriguez as Momo, one of George's employees and friends •
Jaime Camil as Josué Consuelos, Rosie's boyfriend •
Terri Hoyos as Elsa Lopez, George's mother
Guest stars • Jerry Garcia as Mando, one of George's employees who has become a friend • Adam Kulbersh as Jerry, a
Homeowner association member who collects
action figures •
Maria Canals-Barrera as Lily, Rosie's sister • Ana Rey as Flor, Rosie's sister • Nathan Miranda as Robbie •
Constance Marie as Connie •
Valente Rodriguez as Val •
Luis Armand Garcia as Louie •
Belita Moreno as Bella • Michelle Ortiz as Mrs. Garcia, Chance's substitute teacher •
Neil Flynn as Steve, June's father and George's enemy •
Eden Sher as June, Steve's daughter and Mayan's friend • Kensie Mills as Paloma, Steve's granddaughter and June's daughter • Sophia Magaña as Young Mayan •
Harvey Guillen as Miguel, Mayan's cousin •
Jessica Marie Garcia as Yesika, Mayan's cousin • Chelsea Rendon as Luna, Mayan's cousin •
Jacob Vargas as Javier, Rosie's client •
Gregg Sulkin as Dr. Bell •
Justina Machado as Beatrice 'Bunny' Perez, Rosie's friend • Lidia Porto as Gina •
Erik Griffin as Don Patino, Mayan's ex-godfather •
Marilyn Milian as Judge Justicia, a latina TV judge • Jesus Zapien as Mr. Reyes • Julie Wittner as Jenny, a client •
Danny Trejo as Danny Martinez, George's rival •
Melissa Fumero as Natalia, a latina single mom •
Snoop Dogg as Calvin, George's new sponsor •
Gabriel "Fluffy" Iglesias as Iggy, George's sponsor • Vanessa Gonzalez as Gladys, a waitress •
Diana-Maria Riva as Olga, a swap meet vendor • Alexandra Madison as Kylie • Jon Bouffard as Jax •
Tommy Chong as Bryan, Oscar's new friend •
Marshawn Lynch as Marshawn, a sideline reporter •
Jim Plunkett as Himself • Pedro Lopez as Walter •
Scheana Shay as Erica, Justin's husband • Brock Davies as Justin, Erica's wife •
Lisa Rinna as Lisa Perry, George's client •
Jackie Guerrido as Valencia Santa Domingo •
Michael Irby as Father Ramirez, a pastor •
Tisha Campbell as Dr. Glenda Brenda, Mayan's therapist •
Anthony Anderson as Todd Cheeks •
Mini Kiss as Themselves •
Michael Blaiklock as Nick • Meredith Paul as Becky • Al Coronel as Tío Pablo • Eileen Galindo as Tía Angela •
Vicki Lawrence as Ruthie Van Bryan, Quinten's mother •
Jeff Ross as Jeff, a friend of George's • Adrian Gonzalez as Rico •
Annie Gonzalez as Annie Dominguez, Mayan's best friend from high school •
Adam Irigoyen as Orlando, Rosie's nephew • Eli Greenberg as Iker • Hannah Zamora as Yesi •
Brian Posehn as Nicolas, a Mall Santa who reminds George • George Paez as Joseph • Tina D'Marco as Irma •
Francia Raisa as Carina, an entitled social media influencer •
Rizwan Manji as Crispin, an arrogant hardware store employee •
Alexandra Billings as Paula, an exhausted legal mediator who reluctantly presides over Rosie's dispute with her ex-fiance, Josué •
Chris Estrada as Roberto, Quinten's boss • Santino Jimnez as Gabriel • Olivia London Leyva as Sofia •
Mario Lopez as Manny, George's cousin ==Episodes==