Cardinal has had a variety of roles in theatre, film and television. These include
Insomnia,
renegadepress.com,
Crazy Horse and
Wolf Canyon. He is noted for playing
First Nations roles in many productions, including
Tecumseh in ''
Canada: A People's History, an aboriginal elder in Tkaronto, and Davis Quinton, a Cree man, on Corner Gas
. He also appeared on many episodes of North of 60. Cardinal can be heard as the voice of Jacob Morin on the APTN stop motion animated series Wapos Bay: The Series''. In 2011, Cardinal starred alongside
Craig Lauzon in a production of Kenneth T. Williams' play
Thunderstick. The two actors traded roles on alternate days. The same year, he collaborated with
Frank Moher on a production of
Copper Thunderbird at Western Edge Theatre in
Nanaimo, British Columbia. Cardinal completed a documentary film titled
Chasing Lear (2016) with producer
Monique Hurteau; it premiered on
APTN.
Chasing Lear explores the
National Arts Centre theatre production of
King Lear, that had an all-Aboriginal cast. Actors included
August Schellenberg as Lear,
Billy Merasty,
Jani Lauzon,
Tantoo Cardinal, and
Kevin Loring. Lorne Cardinal did double-duty, serving as assistant director and also carrying the role of
Duke of Albany. He recently starred in the award-winning satirical short film 'No Reservations'. The film looks at pipeline politics and was created as a part of the Crazy8's film competition. As of 2020, Cardinal has a recurring role in the network TV drama
FBI: Most Wanted. In 2023, he had a role in the television series Bones of Crows, an expansion of a
film by the same name. ==Personal life==