After two years and 23 major operations, Brissie was able to return to baseball with a metal brace on his leg. He was signed by the Philadelphia A's Connie Mack on December 15, 1946. Mack earlier had encouraged Brissie to hold on to his dream of playing in the majors. Following spring training in 1947, he sent Brissie to the Athletics’ affiliate minor league team in Savannah in the AA
Southern League where his baseball comeback began well when he won 25 games. The A's called him up to Philadelphia and on September 28, 1947, he realized his "life's ambition" of pitching in the major leagues. Brissie's first start of the 1948 season was against the
Boston Red Sox. During the course of the game,
Ted Williams hit a ball up the middle of the field, striking Brissie's leg and causing him to collapse on the mound. "I hit a ball back to the box, a real shot, whack, like a rifle clap,” Williams recalled in his memoir
My Turn at Bat (1969), written with John Underwood. “Down he goes, and everybody rushes out there, and I go over from first base with this awful feeling I’ve really hurt him. Here’s this war hero, pitching a great game. He sees me in the crowd, looking down at him, my face like a haunt. He says, ‘For chrissakes, Williams, pull the damn ball.’" Brissie went on to defeat the Red Sox 4–2, striking out Williams for the game's final out. He pitched three innings for the
1949 American League All Star team. Finishing fifth after a spectacular early start, the A's with pitchers Brissie,
Alex Kellner, and with diminutive pitcher
Bobby Shantz pitching effectively in relief finished fifth in the standings in 1949, one of their best post-
World War II seasons. Brissie was traded to the Cleveland Indians on April 30, 1951. This was part of a three-way trade between the Indians, Athletics and
Chicago White Sox. A notable result of the trade was Cleveland utility player
Minnie Miñoso going to the White Sox where he became the first black major league player in Chicago's history and soon became an All-Star.
Gus Zernial and
Dave Philley went to Philadelphia and were key players the following years for the A's. Brissie retired in September 1953 with a career record of 44–48, with 436 strikeouts and a 4.07 ERA. ==Life after baseball==