•
André LaMothe, American computer scientist and author •
Arthur Lamothe (1928–2013), Canadian-French film director and producer •
Daphne Lamothe, American academic administrator •
Denis Lamothe, Canadian politician •
Dieudonné LaMothe (born 1954), Haitian long-distance runner •
Esteban Lamothe (born 1977), Argentine actor •
Ferdinand Joseph LaMothe (c. 1890–1941), American musician known professionally as
Jelly Roll Morton •
Georges Lamothe (1842–1894), French composer and organist •
Gisou Lamothe (1935–2020), Haitian painter and sculptor •
Jean-Baptiste-Gustave Lamothe (1856–1922), Canadian judge and lawyer •
John Dominique LaMothe (1868–1928), British-American bishop and missionary •
Joseph Lamothe, Haitian politician and briefly interim
President of Haiti in 1879 •
Laurent Lamothe (born 1972), Haitian politician, economist and businessman •
Louis Lamothe (1822–1869), French painter and academic •
Ludovic Lamothe (1882–1953), Haitian composer and pianist •
Lysane Blanchette-Lamothe (born 1984), Canadian politician •
Marc Lamothe (born 1974), Canadian ice hockey player •
Pierre Lamothe (born 1997), Canadian soccer player •
Romeo Lamothe (1914–1991), Canadian politician and teacher •
Ron Lamothe (born 1968), American film director and producer •
Serge Lamothe (born 1963), Canadian writer •
Willie Lamothe (1920–1992), Canadian musician and actor