Wright was born in
LaGrange, Georgia. His father, Ceah Ketchan Wright, was born enslaved but obtained formal education, finishing medical school as
valedictorian but later giving up his medical practice to be a
Methodist minister. Ceah died shortly after Louis's birth and his mother, a sewing teacher named Lula Tompkins, remarried in 1899. Also a physician, Louis's step-father,
William Fletcher Penn, was the first African-American to graduate from
Yale School of Medicine. Penn, who became a prominent doctor in
Atlanta and was the first African-American to own an automobile in the city, had a strong influence on Louis both as a physician and through the racism Louis watched him endure. He completed his postgraduate work at
Howard University-affiliated
Freedmen's Hospital in
Washington, DC before returning to Georgia. He married public
school teacher Corinne Cooke, and the couple had two daughters,
Jane Cooke Wright and Barbara Wright Pierce, both of whom also became physicians and researchers. ==Medical career==