Following her studies at Columbia University, Jefferson began her artistic career designing posters for the
YWCA (Young Women's Christian Association) in New York City, By 1942, she was the publishing company's artistic director, overseeing all aspects of its book productions. In 1960, Jefferson retired from Friendship Press. She would, however, continue to produce work, designing book jacket covers and maps for universities and publishing companies, which documents her research, photographs, and drawings of her visits to Cameroon, the Democratic Republic of the Congo, Egypt, Gambia, Ghana, Guinea, Liberia, Mali, Niger, Nigeria, Senegal, South Africa, Sudan, Uganda, and Zimbabwe; it contains over three hundred of her illustrations. Jefferson kept an art studio in Litchfield, CT during her later years. == Cartography ==