Louise Juliana was the first Dutch born member of the House of Orange-Nassau. She was the eldest daughter of
William of Nassau, Prince of Orange and his third spouse
Charlotte de Bourbon-Montpensier. After her father was murdered in 1584, she and some of her five sisters were raised by their stepmother
Louise de Coligny. On 23 June 1593, Louise Juliana married
Frederick IV, Elector Palatine of the Rhine. The marriage was arranged as a Protestant alliance between one of the most powerful Protestant German rulers and a member of a powerful Dutch Protestant dynasty and she was granted a dowry from both the Dutch estates and king Henry IV of France. The marriage was not happy; Frederick IV was often drunk and unfaithful. Louise Juliana was nevertheless constantly pregnant, giving birth to eight children in just eight years; five of them lived to adulthood. She arranged for her children to be raised by her sister Elisabeth in the principality of Sedan, where they could be shielded from their father and given a Calvinist upbringing. After the death of her husband in 1610, she took part in the regency government in the name of her son
Frederick V, known as "the Winter King." While
John II, Count Palatine of Zweibrücken was formally named regent, she took part in the government alongside him. She was instrumental in arranging the marriage between her son and Elizabeth Stuart in 1613. In 1614, her son was declared an adult and she retired to her dower estate in Kaiserslautern. Louise Juliana tried to convince her son not to accept the Bohemian crown in 1618. When he left for Bohemia with his spouse, Louise Juliana was left in charge of her grandchildren, Charles Louis and Elizabeth, and returned to Heidelberg to act as the adviser of her son's regent John II, Count Palatine of Zweibrücken. In 1620, she was forced to flee the Palatinate, and escaped with her grandchildren to her daughter in Berlin (her grandchildren remained in her care until 1628). When Berlin was besieged by King
Gustavus Adolphus of Sweden in 1631, she was given power of attorney by her son-in-law the Elector of Brandenburg to negotiate, and managed to convince her son-in-law to give in to the Swedish king's demands, thereby saving Berlin from destruction. She left with the Brandenburg court to Königsberg in 1638. ==Issue==