From the west, LA 72 begins on Barksdale Boulevard at its intersection with Hamilton Road. The route heads east on Barksdale Boulevard, a four-lane thoroughfare with a center turn lane. After a short distance, Barksdale Boulevard curves to southeast, connecting with southbound US 71. LA 72 continues straight ahead onto Old Minden Road and intersects
LA 3 (Benton Spur Road), directly opposite a ramp leading to an interchange with westbound
I-20 and northbound US 71. A short distance later, LA 72 passes directly through a
diamond interchange with I-20 at exit 21. Continuing eastward, LA 72 intersects
LA 3105 (Airline Drive) and Northgate Road, leading to the nearby
Barksdale Air Force Base. The highway then curves to the north and simultaneously intersects
LA 782-2 (Industrial Drive). Shortly afterward, LA 72 crosses the
Kansas City Southern Railway (KCS) tracks at grade and passes underneath I-20. LA 72 reaches its eastern terminus immediately afterward at an intersection with the concurrent
US 79/
US 80 (East Texas Street). Average daily traffic volume in 2013 ranged from 7,900 to 12,300 vehicles. The entire route has a posted speed limit of . ==History==