A recent study on the characterization of the venom of this species showed that its biological effects have an intensity similar to that of
Loxosceles laeta,
Loxosceles intermedia and
Loxosceles gaucho, an experimental study with rabbits injected with 0.5 μg (500 nanograms) of the venom resulted in severe
edema, diffuse heterophilic inflammatory infiltrate, perivascular heterophilic infiltrate,
thrombosis in all layers of the
dermis,
fibrinoid necrosis of the arteriolar wall, cutaneous muscle necrosis and dermal
hemorrhage. It is concluded that
L. similis venom induces
apoptosis of
endothelial cells. The minimum, average and maximum amount of venom produced by
L. similis is 0.10 mg, 0.70 mg and 1.5 mg respectively. == References ==