The
MAPEG (Membrane-Associated Proteins in Eicosanoid and Glutathione metabolism) family includes a number of human proteins, several of which are involved the production of
leukotrienes. This gene encodes an enzyme that catalyzes the first step in the biosynthesis of
cysteinyl leukotrienes, potent biological compounds derived from
arachidonic acid. Leukotrienes have been implicated as mediators of
anaphylaxis and inflammatory conditions such as human
bronchial asthma. This protein localizes to the
nuclear envelope and adjacent
endoplasmic reticulum. ==References==