After signing, Campusano made his professional debut with the rookie-level
Arizona League Padres. He spent the whole season there, batting .269 with four home runs and 25 RBI in 37 games. He spent 2018 with the
Fort Wayne TinCaps where he
slashed .288/.345/.365 with three home runs and forty RBI in seventy games and was named a
Midwest League All-Star. Campusano spent 2019 with the
Lake Elsinore Storm, earning
California League All-Star honors. Over 110 games, he batted .325/.396/.509 with 15 home runs and 81 RBI. He was named California League-co MVP (alongside Luis Castro). Following the season, Campusano played for the
Peoria Javelinas of the
Arizona Fall League. in 2022 Campusano was promoted to the major leagues on September 4, 2020, and made his major league debut that night against the
Oakland Athletics, going one-for-three with a solo
home run off reliever
T. J. McFarland. He was placed on the
injured list two days later with a wrist sprain, thus ending his season. To begin the 2021 season, Campusano was assigned to the major league roster before being optioned to the
El Paso Chihuahuas of the
Triple-A West in late April. In June, he was selected to play in the
All-Star Futures Game at
Coors Field. Over 81 games with El Paso, he slashed .295/.365/.541 with 15 home runs and 45 RBI. He appeared in 11 games for the Padres, recording three hits over 34
at-bats. In 2023, Campusano played in only 7 games for San Diego before being placed on the injured list. On May 12, 2023, it was announced that he would miss at least two months after undergoing ligament surgery on his left thumb. He was activated from the injured list on July 18. Campusano made 49 total appearances for San Diego, batting .319/.356/.491 with seven home runs and 30 RBI. Campusano made 91 appearances for the Padres during the 2024 campaign, hitting .227/.281/.361 with eight home runs and 40 RBI. Campusano was optioned to Triple-A El Paso to begin the 2025 season. ==Personal life==