Manzano started his career as an image model for clothing brand, 'Human'. He later pursued a television host and acting career. Manzano began his professional trajectory by working as a
VJ for the renowned music channel,
Myx, with
Iya Villania. He later served as a host and performer on the television veriety show
ASAP in 2003, and on the reality show
Star Circle Quest in 2004. Following his hosting engagements, Manzano transitioned into acting, portraying the roles of Luigi in the sitcom series
Bora and Pablo in the drama
Kampanerang Kuba, both of which aired in 2005. In addition to his television work, Manzano was also part of the main cast in several films in consecutive years, including
All About Love as Wesley (2006),
Ang Cute ng Ina Mo! as Val Quizon (2007),
In My Life as Mark Salvacion (2009),
Hating Kapatid as Edzel (2010), and
Petrang Kabayo as Erickson Santos (2010). Manzano starred in the comedy film
Moron 5 and the Crying Lady in 2012 and its
sequel in 2014, as well as in ''
This Guy's in Love with U Mare!'' as Mike, also in 2012. Manzano returned to hosting in 2007 through the talk show
Entertainment Live, alongside
Toni Gonzaga,
Mariel Rodriguez, and
Bianca Gonzalez. That same year, Manzano also co-hosted the reality game show
Pinoy Big Brother: Teen Edition Plus with them. In 2010, he hosted the game show ''
Panahon Ko 'To!: Ang Game Show ng Buhay Ko with Billy Crawford. He also co-hosted the reality talent competition Pilipinas Got Talent with Crawford from 2010 to 2016. In 2011, Manzano starred in the sketch comedy show Laugh Out Loud alongside Alodia Gosiengfiao. Manzano replaced Kris Aquino as host of the game show Kapamilya, Deal or No Deal from 2012 to 2016 and since 2026. In the same year, Manzano co-hosted the musical variety show Sarah G Live with Sarah Geronimo. He also hosted the game show Minute to Win It'' from 2013 to 2019. From 2014 to 2015, Manzano served as host for both
The Voice Kids and
The Voice of the Philippines. Manzano replaced Billy Crawford as host of the game show
Celebrity Playtime, which aired from 2015 to 2016. He then succeeded his father,
Edu Manzano, as host of
Family Feud from 2016 to 2017, before being replaced by
Dingdong Dantes in 2022. Manzano was the original host of the talent competition
The Voice Teens in 2017. In 2019, he hosted the interactive reality competition
World of Dance Philippines alongside
Pia Wurtzbach. Manzano later replaced Billy Crawford as host of Season 3 of the singing and impersonation competition
Your Face Sounds Familiar. He also headlined the variety show ''
It's Your Lucky Day. As of 2024, Manzano serves as the host of the game show Rainbow Rumble. In October 2025, Manzano returned to hosting Pinoy Big Brother after seventeen years through Pinoy Big Brother: Celebrity Collab Edition 2.0''. == Political career==