During the 17th century, there was an area of land in Laguna known as Terreno De Nasunog or Lupain ng Nasunog, that was part of
Majayjay, Laguna. The name "Luisiana" was given in honor of Don Luis Bernardo and his wife Doña Ana Esperanza, who fought for the Independence of Luisiana. In 1825, Don Luis Bernardo, one of Nasunog de Majayjay's principales, initiated the move to establish it as a town and parish separate and independent from Majayjay. However, it was only in 1832 when Nasunog de Majayjay was elevated to a visita which was later called Visita de Luisiana. The original Name is "Luis y Ana" And later became the town of Luisiana. It was only on April 3, 1854, that ecclesiastical independence was granted to San Luis by the Governor-General (
the Marqués de Novaliches) with the corresponding approval from the Archbishop of Manila, having Don Marcos Bartolomé as its first interim parish priest. Because of the role of Don Luis Bernárdo, which was then regarded as the Father of Luisiana, and his wife Doña Ana, the town was named 'Luis y Ana', later changed to 'Luisiana'. The town's Catholic church, which is dedicated to
Our Lady of the Rosary, was established in 1854 but burned down in 1872 before being rebuilt. In 1903, the towns of
Cavinti and Luisiana were combined, Pedro Villanueva of Cavinti was elected mayor and it was during his term that the
Aglipay Church was founded in April 1904. The Romana family funded the construction of a couple of Protestant churches. However, in 1907, during the leadership of Don Blas Oración, through the Civil Commission, Cavinti separated from Luisiana and became an independent town. ==Government==