Melbourne Jackson was recruited by Melbourne with pick 3 in the
2019 AFL draft. Jackson debuted in the
Demons' one-point win over the
Carlton Blues in the second round of the
2020 AFL season. He collected 7 disposals, 1 behind and 1 tackle. After being omitted for the next 3 rounds, Jackson re-entered the team in Round 7. He won the
Rising Star nomination for Round 10. In that game he kicked 2 goals, including the opening goal. On top of that, he also collected 8 disposals, 14 hitouts and 2 marks. At the conclusion of the year he took out the
Harold Ball Memorial Trophy, an award given to the best young talent for the
Melbourne Demons. Jackson re-signed for a one-year contract extension at the end of the year, keeping him at the club until 2022. and won the award overall at the season's conclusion. Jackson was a part of Melbourne's 57 year drought breaking
Grand Final victory over the
Western Bulldogs. Following Melbourne's loss to the
Brisbane Lions in the 2022 semi-final, Jackson reportedly met with the club and formally requested a trade to his home state of
Western Australia, however he did not nominate a specific club and allowed offers from both
West Coast and
Fremantle. Jackson was traded to Fremantle on 10 October for a first-round pick, a future first-round pick and a future second-round pick. Upon joining Fremantle, Jackson signed a seven year contract, tying him to the Dockers until at least 2029.
Fremantle He made his debut for Fremantle in round one of the
2023 AFL season against at
Optus Stadium. Round 15 saw Jackson collect 17 disposals, 9 score involvements and kick three goals during Fremantle's 32 point win over . Jackson made the line-up for Fremantle's opening game of the
2024 AFL season against the at Optus Stadium. He was named as the sole ruckman, after fellow ruckman and teammate
Sean Darcy was ruled out due to injury.{{cite news|last=Barrett|first=Jackson|title=Fremantle Dockers confirm Sean Darcy’s injury timeline, but Luke Jackson says he is ready to fill the void ==Statistics==