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Thoracic duct

In human anatomy, the thoracic duct is the larger of the two lymph ducts of the lymphatic system. The thoracic duct usually begins from the upper aspect of the cisterna chyli, passing out of the abdomen through the aortic hiatus into first the posterior mediastinum and then the superior mediastinum, extending as high up as the root of the neck before descending to drain into the systemic (blood) circulation at the venous angle.

Structure
In adults, the thoracic duct is typically 38–45 cm in length and has an average diameter of about 5 mm. The vessel usually commences at the level of the twelfth thoracic vertebra (T12) and extends to the root of the neck before descending to terminate at the venous angle. Origin The thoracic duct commences at the upper extremity of the cisterna chyli at the level of the T12 vertebra. and is situated posterior to the esophagus at the T7 vertebral level. It crosses the midline to the left side at about the T5 level, continuing to ascend. It then passes posterior to the aorta, and to the left of the oesophagus. In the superior mediastinum, the thoracic duct is situated posterior to and to the left of the esophagus. It is situated between the visceral and alar fascia. It passes posterior to the left common carotid artery, vagus nerve (CN X), and internal jugular vein. At C7 level, it lies posterolaterally to the carotid sheath. From here, it passes anteroinferiorly to the thyrocervical trunk, and phrenic nerve. It descends until reaching and draining at the venous angle. Fate The thoracic duct usually drains into the systemic (blood) circulation at the left venous angle where left subclavian and left internal jugular veins unite to form the left brachiocephalic vein. Variation The characteristic anatomy of the thoracic duct is present in only about half of individuals. Origin A cisterna chyli is absent in about half of individuals; the cisterna chyli fails to develop when the fusion of lumbar trunk during embryologic development occurs above the vertebral level of T12. In such cases, dilation of the lumbar trunks may be present instead. Number of ducts A bifid inferior portion of the thoracic duct (due to a failure of fusion during embryonic development) is not uncommonly observed; a plexus of lymphatic vessels replacing the thoracic duct inferiorly and only coalescing into a single duct in the mediastinum may also occur. Rarely, the thoracic duct may be entirely bilaterally paired. Termination In over 95% of individuals, the thoracic duct ends by draining either at the venous angle, or into the internal jugular vein, or the subclavian vein, but - in the minority of cases - empties into either the brachiocephalic vein, external jugular vein, suprascapular vein, transverse cervical vein, or vertebral vein. In a vast majority of cases, the thoracic duct terminates on the left side, but may rarely terminate on the right side of the body, or bilaterally. It usually terminates as a single vessel, but it sometimes ends in bilateral vessels or as several terminal branches. Rarely, the thoracic duct terminates "prematurely" by emptying into the azygous system. ==Function==
Function
The thoracic duct collects most of the lymph in the body other than from the right thorax, arm, head, and neck. These are drained by the right lymphatic duct. ==Clinical significance==
Clinical significance
The thoracic duct becomes adaptively dilated in the presence of certain pathological conditions (congestive heart failure, portal hypertension, and malignancy). The first sign of a malignancy, especially an intra-abdominal one, may be an enlarged Virchow's node, a lymph node in the left supraclavicular area, in the vicinity where the thoracic duct empties into the left brachiocephalic vein, right between where the left subclavian vein and left internal jugular join (i.e., the left Pirogoff angle). When the thoracic duct is blocked or damaged a large amount of lymph can quickly accumulate in the pleural cavity, this situation is called chylothorax. ==Additional images==
Additional images
File:Gray503.png|Transverse section of thorax, showing relations of pulmonary artery. The thoracic duct is the centrally located, small, triangular space behind the esophagus. File:Gray505.png|The arch of the aorta, and its branches. File:Gray621.png|Deep lymph nodes and vessels of the thorax and abdomen (diagrammatic). File:Gray1032.png|The position and relation of the esophagus in the cervical region and in the posterior mediastinum. Seen from behind. File:Photo of Ductus Thoracicus in human mediastinum.jpeg|Front photo of the ductus thoracicus in the human mediastinum with the heart and part of the pericard removed. ==See also==
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