M. Daniel Lane

Lane was born in Chicago, Illinois on August 10, 1930, to Malcolm Daniel Lane Snr, an accountant at the Herald Tribune and Helga Wilke who was of Danish origin. He attended Iowa State University and received his B.S. in 1951 and his M.S. in 1953. He then moved to the University of Illinois at Urbana-Champaign and received his Ph.D. in biochemistry in 1956. ==Academic career==

Lane began his faculty career immediately after finishing his Ph.D. with an appointment as an associate professor at the Virginia Polytechnic Institute, where he advanced to full professor in 1963. After a brief sabbatical in Munich, Germany to work with Feodor Lynen, he moved from Virginia Tech to the New York University School of Medicine in 1964. Lane was recruited to the Johns Hopkins School of Medicine by Albert Lehninger, chair of what was then known at the Department of Physiological Chemistry, in 1970. Lane subsequently succeeded Lehninger as department chair in 1978, changing the department's name to Biological Chemistry, and served in that position until 1997. Lane retired from his faculty position, assuming professor emeritus status, in 2008. ==Research==

In the early phases of his career, Lane was primarily interested in vitamins and vitamin metabolism, particularly in biotin-dependent enzymes such as propionyl-CoA carboxylase and acetyl-CoA carboxylase, which he studied in and purified from calf and chicken livers. This work was later recognized as classic in the field by the Journal of Biological Chemistry. His interest in vitamins and nutrition led him to focus later on lipogenesis and its regulation. Lane's laboratory published widely cited early studies of the insulin receptor and made extensive use of the 3T3-L1 cell line for investigating cellular differentiation processes leading to adipocytes. After the discovery of the satiety-regulating hormone leptin, Lane's laboratory focused its efforts on characterizing its regulation. ==Personal life==

Lane met and married his wife Patricia during his time at Iowa State. The couple had two children Danny Lane and Claudia Lane. Lane was an enthusiastic fisherman who enjoyed fishing and boating on the Chesapeake Bay. He was involved in local social justice and environmental activism. Lane died of myeloma on April 10, 2014. ==Awards and honors==

• Received the American Institute of Nutrition's Mead-Johnson Award, 1966 • Received a National Institutes of Health MERIT award, 1990 • Elected to the American Society for Nutritional Sciences, 1996 • Named Johns Hopkins University Distinguished Service Professor, 2001 ==References==