Having secured the support of a powerful prince,
Andrey Shuisky, Macarius was elected Metropolitan of Moscow and all Russia on 16 March 1542. During
Ivan IV's nonage and Shuiskys'
regency, Macarius's relations with the
Boyar Duma gradually worsened due to his constant "grief" over the disgrace of courtiers and church dignitaries. His independent-mindedness induced a number of attempts to dislodge him. In the summer of 1544, Macarius escaped a sure death in the fire raging in the
Moscow Kremlin. Three years later, he took part in removing Ivan's maternal relatives, the Glinskys, from the Russian government. Upon becoming one of the closest advisers of Ivan the Terrible, Macarius arranged his
coronation on 16 January 1547. That year, he blessed the tsar's marriage with
Anastasia Zakharyina-Yuriyeva. Macarius was an active participant at the
zemsky sobors of 1547, 1549, and 1550, advocating conciliation between the opposing boyar groups. During the
synod of 1542, Macarius achieved the
excommunication of
Maximus the Greek's associate Isaac Sobaka, archmandrite of the
Chudov Monastery. Macarius would later correspond with the exiled Maximus the Greek and include some of his essays in his the Great Menaion Reader, rejecting, however, his appeals for pardon. During the
Stoglav Synod and other such synods, traditionally known as Macarius's synods in Russian historiography, Macarius carried out the
canonization of 39 all-Russian saints. In 1551, Macarius, together with the tsar, convened the Stoglav Sobor. He also blessed the Russian army before its departure to
Kazan in 1552. During his Kazan campaign in 1559, Ivan the Terrible left Macarius in Moscow to "protect the tsardom", which made him a temporary head of state. In 1552 and 1554, Macarius completed the second and third editions of the
Grand Menaion. During the church councils in 1553–1555, Macarius supported the accusations of
heresy, aimed at a boyar son
Matvei Bashkin,
starets Artemiy, and monk Feodosiy Kosoy. However, he took the side of
Sylvester, a monk at the
Cathedral of the Annunciation in the Moscow Kremlin, who had been accused by
diak Ivan Viskovatyi in uncanonical wall-painting of the above-mentioned cathedral. When the tsar was away from
Moscow, Macarius was in charge of diplomatic negotiations and dispatching messengers abroad with different
deeds. The painting of the
Saint Basil's Cathedral and the Kremlin's
Golden Chamber was carried out with his assistance. He also took part in compiling the
Chronicle of the Beginning of Tsardom of Tsar and Grand Prince Ivan Vasiliyevich, i.e., an official
chronicle of Ivan the Terrible's reign and the
Regal Book, an
illuminated manuscript about Ivan's reign and policies. ==Later years==