MacKillop Catholic Regional College is a Catholic secondary school in Werribee, Victoria, Australia. It has strong connections to the Josephite sisters, founded by Mary MacKillop. The college was founded as Mary McKillop Girls College in 1970, providing junior secondary education to female students in Years 7, 8 and 9. As demand for secondary education grew in the area, the College expanded to cater to male and female students from Years 7 to 12 and changed its name to reflect these changes. In 2022, MacKillop reached their 50 year anniversary, however celebrations were curtailed due to the COVID-19 pandemic.