Macrocranion is a genus of extinct mammal from the Eocene epoch of Europe and North America. Exceptional fossils have been found in the Messel Pit of Germany. Macrocranion species are often described as forest-floor predators, about the size of small squirrels but with longer limbs. The genus is represented at the Messel Pit site by two species, M. tupaidon and M. tenerum.