Born in
Bayreuth, she was her parents' fifth child. Her maternal grandparents were
Albert Frederick, Duke of Prussia, and
Marie Eleonore of Cleves. One of her maternal aunts was
Duchess Anna of Prussia. She had three surviving siblings: Anna Maria (1609–1680), wife of Prince Johann Anton I von
Eggenberg,
Duke of Krumlov;
Erdmann August (1615–1651); and
George Albert (1619–1666). She was married to
John George,
Prince Elector of Saxony, on 13 November 1638 in
Dresden. He was her first cousin, being the son of her maternal aunt and namesake,
Magdalene Sibylle of Prussia. Her sister-in-law and cousin was
Magdalene Sibylle of Saxony. Magdalene Sibylle had a good relationship with the Swedish royal family (the Queen consort from 1620 to 1632,
Maria Eleonora of Brandenburg, was her first cousin) and was able to save the city of
Pirna from attack by a letter to the Swedish commander in 1639, during the
Thirty Years' War. In 1680 she was widowed and retired to Freiberg-Colditz. She died in
Dresden in 1687. ==Issue==