It is known to act on the
GABAA receptors in rat cells
in vitro as well as having antifungal properties. Magnolol has a number of osteoblast-stimulating and osteoclast-inhibiting activities in cell culture and has been suggested as a candidate for screening for anti-osteoporosis activity. It has anti-periodontal disease activity in a rat model. Structural analogues have been studied and found to be strong allosteric modulators of GABAA. Magnolol is also binding in dimeric mode to
PPARγ, acting as an agonist of this nuclear receptor. Magnolol may interact with
cannabinoid receptors, acting as a partial agonist of
CB2 receptors, with lower affinity for the
CB1 receptor. == References ==