Maïnassara was killed in another military coup in April 1999, and new elections were held in late in the year. In the first round of
the presidential election, held in October, Issoufou placed second, winning 22.79% of the vote. He was later defeated by Mamadou Tandja in the November run-off, capturing 40.11% of the vote compared to Tandja's 59.89%. He was backed in the second round by the unsuccessful first round candidates
Hamid Algabid,
Moumouni Adamou Djermakoye, and
Ali Djibo, while Tandja received Ousmane's support. After the announcement of the provisional results showing Tandja's victory, Issoufou accepted them and congratulated Tandja. In a repeat of the 1999 election, Issoufou placed second behind incumbent Tandja in the
2004 presidential election, winning 24.60% of the vote. however, that was still considered an impressive result for Issoufou, as he had substantially increased his share of the vote even though the other first round candidates had backed Tandja in the second round. Issoufou, who targeted corruption in his campaign, accused Tandja of using state funds for his own campaign, along with other accusations of electoral misconduct, and said that the election was not as transparent as the 1999 election. In the
December 2004 parliamentary election, Issoufou was re-elected to the National Assembly as a PNDS candidate in Tahoua constituency.
2009 political crisis In 2009, the PNDS strongly opposed Tandja's efforts to hold
a referendum on the creation of a new constitution that would allow him to run for re-election indefinitely. At an opposition rally in Niamey on 9 May 2009, Issoufou accused Tandja of seeking "a new constitution to stay in power forever" and the establishment of "a dictatorship and a monarchy". As leader of the Front for the Defence of Democracy (FDD) opposition coalition, he said on 4 June 2009 that a planned anti-referendum protest would be held on 7 June despite an official ban. As part of the
constitutional dispute, Tandja assumed emergency powers on 27 June. Accusing Tandja of undertaking a ''coup d'état'', "violating the constitution and ... forfeit[ing] all political and moral legitimacy", Issoufou called on the armed forces to ignore his orders and urged the international community to intervene. Issoufou was detained at his home by the army's paramilitary police on 30 June; he was questioned and released after about an hour. A nationwide strike called by the FDD was held on 1 July and was deemed partially successful by the press. The referendum was held on 4 August 2009, despite the opposition's furious objections and calls for a boycott, and it was successful. Speaking on 8 August, shortly after the announcement of results, Issoufou vowed that the opposition would "resist and fight against this ''coup d'etat'' enacted by President Tandja and against his aim of installing a dictatorship in our country". On 14 September 2009, Issoufou was charged with misappropriation of funds and then released on bail. He said that he was actually charged for political reasons. He left the country. On 29 October 2009, international warrants for the arrest of Issoufou and Hama Amadou were issued by the Nigerien government, and Issoufou returned to Niamey from
Nigeria late on 30 October in order "to cooperate with the judiciary". Tandja was ousted in a
February 2010 military coup, and a new transitional
junta enabled the opposition leaders to return to politics in Niger while preparing for elections in 2011. At a meeting in early November 2010, the PNDS designated Issoufou as the party's candidate for the
January 2011 presidential election. Issoufou said on the occasion that "the moment has come, the conditions are right", and he called on party members to "turn these conditions into votes at the ballot box". Some observers considered Issoufou to be potentially the strongest candidate in the election. ==Presidency (2011–2021)==